I₂-catalyzed Synthesis Of Substitued Indolizines And Imidazoles

Nowadays, when we enjoy the material civilization, we are also confronted with the more and more serious situation which is resource exhaustion, environmental deterioration, ecosystem degeneration and so on. Therefore, it is necessary to develop a series of organic synthesis strategies, which was environmental, economical, efficient and novel. In the past several years, the reaction of transation-metal catalysis and cyclization had been developed rapidly. However, most of strategies had similar drawbacks such as toxicity, heavy pollution and hard degradation. Thus, low-cost and harmfulless metal-free catalysts have drawn more attentions. Iodine/iodide oxidition as potential a reaction system, it was also easily prepared and operated when iodide or iodine were served as catalysts. Moreover, most of oxidant, such as oxygen, hydrogen peroxide, TBHP and other oxidants. Therefore, the reaction system of iodine /iodine oxidation were extensively applided to C–H bond activation and C–C/C–N bonds construction.Herein, we had mainly reported several methods of synthesis substituted indolizines and imidazoles, which were use simple substrates with iodine-catalyst. Indolizines and the derivatives are a class of valuable heterocyclic compound, and exsist extensively in the natural product, medical chemistry, organic synthesis and the domain of material. We had successfully developed a method of synthesize substituted indolizines between styrenes and C2 functionalization of pyridines with iodine-catalyst. This strategies had many advantages,such as the substrates were easier to be preparatd, the derivatives of benzene were tolerated. Moreover, we also developed a feasible strategies of synthesize substituted indolizines between styrene and C2 functionalization of pyridines, with iodine as catalyst and TBHP as oxidant substituted.we got new cognition in synthesis heterocyclic compounds with iodine-catalyst. Vinyl azides is one of the important substrates that our group is researching. To our knowledge, the new method for synthesis of substituted imidazoles with vinyl azides is still appreciated. Inspired by the studies of utilization of vinyl azides and our experiences in the development of new and efficient methods for the construction of heterocyclic compounds, herein, we report a novel and facile approach to obtain substituted imidazoles from vinyl azides and benzylamines catalyzed by iodine.