Design And Charaterization Of Multi-Stimuli Responsive, Self-Healing Hydrogel

The stimuli-triggered degradable hydrogels have found broad applications in controlled release of drugs,3D cell culture and tissue engineering. On one hand, to significantly improve the safety and prolong the lifetime of man-made materials, self-healing systems that can spontaneously repair their damage are drawing more and more attentions in the past few years. On the other hand, recently, multi-stimuli responsive micelle-based hydrogels has become focus, since they could respond to a combination of external stimulus. The main contents of this thesis is as follows.(1) We present here a P(AM-co-DMAPS) zwitterionic copolymer based self-healing hydrogel, where AM and DM APS are acrylamide and 3-((2-(methacryloyloxy)ethyl)dimethylammonio)propane-1-sulfonate, respectively. The electrostatic interaction between DMAPS and hydrogen bonding between AM moieties contribute to physically cross-linking of the polymer chains and self-healing ability of the hydrogel. The reported strategy represents a general and facile route to construct zwitterionic copolymer based self-healable functional hydrogel for potential application in the field of enhanced oil recovery (EOR).(2) We prepared a multi-stimuli responsive supramolecular hydrogel with great potential to biomedical application, which composed of the micelle-forming diblock copolymer poly[(N-isopropylacrylamide-co-2-nitrobenzyl acrylate)-block-(N,N-dimethylacrylamide-co-acrylic acid)] (P(NIPAM-co-NBA)-b-P(DMA-co-AA)), and physically cross-linked by supramolecular complexation between AA groups and ferric ions (Fe3+), exhibiting gel-sol transition by UV irradiation, multidentate ligands (EDTA) and redox agent (Na2S2O4).