The Preparations On Superhydrophobic Surfaces With Different Stiffness And Related Researches On Cells Adhesion

With the progress and development of the society, the expectation and requirements of human beings for biological materials are increasing due to the good willing of curing disease and improving living standards. In particular,polymer biomaterials which have the irreplaceable advantages over many metallic and inorganic materials, has made a rapid progress. Polymer hydrogel materials have been widely applied in the field of tissue engineering scaffolds and drug delivery systems because of its high moisture content, favorable biocompatibility and low friction coefficient. As for implantable medical polymer hydrogel materials, not only should they match the mechanical property with the original tissues but also avoid the lesion caused by adhesion and proliferation of possible residual diseased cells on the material surface. Thus,the synergistic effect of surface comprehensive regulation in material hardness and ultra-wetting characteristics which inhibit cell proliferation offers a new direction for designing practical implantable materials.This paper achieves the control of the mechanical property and surface structure for polymer materials with good biocompatibility by template method and adjusting the ratio of crosslinking agent. Additionally, we implement their ultra-wetting characteristics via constructing micro/nano composite structure on surface of the membrane. We have successfully investigated the impacts ofsynergy on the physical activities such as the adhesion of hepatic carcinoma cells etc. Then we summarize the regularity of interaction between cells and material surfaces and further optimize the adhesion and differentiation of cells.To conclude, we hope our work can provide some valuable guidance for further materials design in the applicaiton of tissue engineering scaffold.