Research On Organic Reactions By Coenzyme NADH Model

In recent years, research on biomoleculars attracts a lot of researchers. An NADH coenzyme model is a key compound among biomoleculars. NADH coenzyme model can take part in a lot of chemistry reactions. Compared with metal catalysts, NADH coenzyme model is more environmentally friendly and less waste. We first introduce several kind of NADH coenzyme model, such as BNAH, AcrH2, and HER Then summarize the reactions promoted by them. In our work, we research on AcrH2 and HEH, and find some results.We try to use AcrH2 to promote reaction, and find benzothiophenes are gotten in visible light using o-methylthio-arenediazonium salts and alkynes. Benzothiophene derivatives are applicated widely in biology, pharmacy, and material science. This method provides novel, mild, environment-friendly and efficient access to benzothiophene derivatives avoiding high temperature and metal-catalysts. Instead, only a catalytic amount of AcrH2 is required. The scope of substrate is wide. The products have the potential for further synthesis of some key chemistry and drug intermediate.We research on reductive amination using HEH for synthesis of asymmetric secondary amines. Inorganic ammonium formate provides the nitrogen source. Two different kinds of aromatic aldehydes can be successfully coupled. Moreover, it is not influenced obviously by electron-donating or electron-withdrawing groups. The reaction conditions are mild, convenient, acid-free and applicable to sensitive substrates. Furthermore, no heavy metals are introduced into the system. A polymer is obtained accidently in our further research. Thus, our developed method provides a new channel for the preparation of polymeric materials.