Study On Chiral Metal - Organic Skeleton Material Used As High Performance Liquid Chromatography Stationary Phase

The main works of the thesis were listed as follows:A brief introduction for chirality and the meaning of chiral separation, the optical resolution methods, the enantioseparation in high performance liquid chromatography, the research and development of metal-organic frameworks were given.Using a homochiral MOF [Co2(D-cam)2(TMDPy)] as chiral stationary phase for separations of racemates and positional isomers, the influence of the mobile phase composition was discussed, and the separation of six positional isomers and six chiral compounds were obtained. The reproducibility and stability of the column were discussed.Chiral MOFs [Cu(L-tart)(bipy) ? 2.33 H2O] and {[Co0.5Zn0.5(L-Tyr)]n(L-tyrCo/Zn)} were packed into two stainless steel empty columns, respectively. [Cu(L-tart)(bipy) ? 2.33 H2O] column separated three racemates and four positional isomers. {[Co0.5Zn0.5(L-Tyr)]n(L-tyrCo/Zn)} column separated four racemates.We comfirmed that chiral MOFs [Zn2(BTC)(NO3)(DMA)3] 、Fe2(D-cam)2(TMDPy) 、 [Mg(L-tart)(H2O) ? 1.5H2O] and {[Co6(μ3-OH)2(IN)4(HCOO)6] ? 4DMF 5H2O}n possess poor separation abilities for racemates in HPLC.Coating mixture of [Co2(D-cam)2(TMDPy)] and cellulose tris(3,5-dimethylphenylcarbamate) on silica gel, whether the use of chiral MOF can enhance the enantioseparation of cellulose derivative was investigated.