Preparation And Properties Of Novel Polymeric Medical Adhesive

Mussels can, firmly, adhere the surface of various substrates by secreting mussel adhesive proteins, which was an enlightment. The development of such similar biological adhesive attracted wide attention and interest of researchers. Studies have shown that molecular chain with amino acid fragments of DOPA is the key reason for mussel adhesive proteins with superior adhesion capabilities. So bonding the catechol functional groups to the polymer chain can obtain a biomimetic polymer adhesive with the similar property as mussel adhesive protein. A lot of work in this field has been studied by researchers at home and abroad, which has get several kinds of new polymer medical adhesion. This study was put forward on the basis of the temperature in response to polymer, at the same time, it introduced dopamine, arginine and other reactive functional groups to its chain. They preparaed the new biological medical adhesives with high strength which can be rapidly solidified.This study used two or more temperature-responsive hydroxy polyether L-31(PEL-31) as the initiator, causing L-2,4-dihydroxy benzyl amino acetic acid-N-carbonyl anhydride(DOPA-NCA), arginine-N-carbonyl anhydride(Arg-NCA), cysteine-N-carbonyl anhydride(C ys-NCA) and ε-N-acrylamide lysine-N-carbonyl anhydride(AM- Lys-NCA) ring opening polymerization. Polymer adhesives with several different structures was obtained, which was temperature-responsive. The structure, average molecular weight and temperature responsive property of high polymer adhesives were tested. And we used pigskin of different thickness as base material for simulating adhesive test of the polymer adhesives, and the results show that these polymers have bonding ability, the bonding ability of polymer with guanidyl, sulfydryl and double bond functional group on its side is much stronger. The highest compressive strength of polymer with dopamine, guanidyl, sulfydryl and double functional group on the molecular chain is close to 1.25 Mpa, which is better than the vast majority of similar bionic polymer adhesives reported in literatures. The lowest critical solution temperature(LCST) is proved to be about 35 ℃ by the temperature-responsive test.Because the PEL- 31 hasn’t biodegradability, so this thesis used L-glutamic acid diethylene glycol monomethyl ether acetate as raw material. It obtained polypeptides type temperature response and biodegradable polymer through ring opening polymerization. DOPA NCA, Arg-NCA, Cys-NCA and AM-Lys-NCA co-polymerization were made, and a series of polypeptide type temperature response and biodegradable polymer bionic adhesion were obtained. The structure, average molecular weight, temperature-responsive property and degradability of high polymer adhesives were tested. and different thickness of pigskin were used as base material for simulation adhesive test of the polymer adhesives. Results show that these polymers have bonding ability, and the bonding ability of polymer with guanidyl, sulfydryl and double bond functional group on its side is much stronger. The highest compressive strength of polymer with dopamine, guanidyl, sulfydryl and double functional group on molecular chain is close to 1.03 Mpa, which is better than the vast majority of similar bionic polymer adhesives reported in literatures. The lowest critical solution temperature(LCST) is about 33 ℃ by the temperature-responsive test. The results of degradability test show that the adhesives can be degraded, and 60% of polymer adhesives were degraded after 15 days.