The Study On Transition Metal-catalyzed Cyclization Then Cross-Coupling Tandem Reaction

Organic chemical reactions catalyzed by transition metals have been a lot of development. However, many catalysts are from precious metals or heavy metals, the price is relatively expensive, or have a certain degree of pollution on the environment, or both, which makes these metals derived from catalysts in industrial large-scale application has been greatly limit.Given its low price, non-toxicity and environmentally benign character, which often offers notable advantages in terms of sustainable chemistry, some transition metal catalysis(Cu, Ni, Co, Fe, et.al) represents hence an attractive alternative to other commonly used transition metals. However, judging from the explored research, the iron or copper-catalyzed organic reactions still have a long way to go. In this thesis, we made a detailed study on the transition metal-catalyzed tandem reaction(radical cyclization then cross-coupling), which concerns on the the preparation of the precursors of indane derivatives, indoline derivatives and benzofuran derivatives, and the reaction condition optimization for the synthesis of the target molecules. Furhtermore, a series of phenyl-thioureido-sulfides were synthesized by using boronic acid as the starting molecular with copper salts as the catalyst. These methodologies might be of high practical value for modern chemistry and chemical industry, and might pave an efficient route to the synthesis of a number of potentially pharmaceutically and biologically active molecules.