Synthesis, Structures And Properties Of Transition Metal Complexes Constructed From 2-Methyl-4-Oxazole Carboxylic Acid

Oxazole (Isoxazole) and its derivatives are one of the most important biological activity materials in the fields of pesticides and pharmaceuticals. They have multi-function of insecticide, weeding, anticancer, anti-parasitic and so on. Since 1972, Nobartis exploited organophosphorus insecticide, azamethiphos, some foreign drug companies have successfully developed dozens of herbicides, insecticides and fungicides containing pyrazole rings. Because oxazole complexes have excellent biological activities of low toxicity to human body and high efficiency, the syntheses and biological activities research are the green pesticide and medicine to the new field.Some complexes are designed and synthesized by using 2-methyl-4-oxazole carboxylic acid as first ligand,1,10-phenanthroline (Phen) as auxiliary ligand. We also carried out a pilot study on the interaction between calf thymus DNA (ct-DNA) and antiproliferative activity of the compounds. The main work is as following:1. Chapter one:A brief summary about the synthesis, pesticide biological activity, research process of oxazole carboxylic acid derivatives and the study of the plant activator were described.2. Chapter two:Using 2-methyl-4-oxazole carboxylic acid acts as first ligand,1, 10-phenanthroline (Phen) as auxiliary ligand, nine transition metal complexes were synthesized by traditional solution methods, the single crystal of all of which were all obtained. The composition of these complexes was analyzed elemental analysis, IR spectra and TGA. The general formula of complexes can be presented as:[AgL]n (1), [MnL2(H2O)2]n (2), [CoL2(H2O)2]n (3), [CuL2(H2O)2]n (4), [ZnL2(H2O)2]n (5), [CdL2(H2O)2]n (6), [NiL2(phen)]·4H2O (7), [MnL2(phen)]·5H2O (8), [ZnL2(phen)]·5H2O (9).3. Chapter three:Nine complexes were analyzed the crystal structure and explain the reasons of them in the crystallography theory.4. Chapter four:The interaction of HL and nine complexes with DNA are studied by EB fluorescent probe. Compared the constants Ksq, the result show all complexes can insert into DNA in different degrees, the binding ability of the complex 5 is the weakest, while complex 7 is the strongest. Except complex 2 to 6, the binding abilities of complex 7 to 9 are stronger than HL. Compare with the ten compounds, complex 7 to 9 have the strongest interaction with the DNA because of adding the big phen planar molecules while the other three complexes are in the smaller intensity (related to the HL ligand) and could release some free EB form EB-DNA, which could be ascribed to the compounds had already inserted into the DNA structure. In the interaction between HL, complex 2 to 9 binding with BSA, complex 1 is the strongest one. All the complex and the ligand can bind with DNA and BSA in different degree.