Synthesis And Characterization Of Arylimidazole Derivatives Containing Nitro Group

By using phenanthrenequinone, ammonium acetate, aminoheterocycle and different positions substituted nitrobenzaldehyde, different locations nitro-substituted imidazole derivatives with the one-pot method was synthesized. We use phenanthrenequinone, p-nitrobenzaldehyde, ammonium acetate and Aniline as a reaction model with microwave assistance to synthesize nitrobenzaldehyde three phenyl-substituted imidazole, by examining the reaction feed ratio of raw materials, reaction temperature, reaction time and other factors, General conditions were obtained under microwave synthesis conditions for optimum conditions to synthesize nitro groups containing three phenyl imidazole. By then with the preferred conditions, the reaction structures was expanded and also benzil was replaced with phenanthrenequinone, o-nitrobenzaldehyde was replaced with nitrobenzaldehyde to use one-pot reaction to pepare phenyl-substituted benzimidazole derivatives phenanthrenequinone.It can be concluded that, phenanthrenequinone and benzil categories dione compounds as substrates, m-nitrobenzaldehyde and p-nitrobenzaldehyde as aldehyde substrate, aminopyridine, aminothiazole and aniline as ammonia source are suitable for the one-pot method. Nitro-group imidazole and benzimidazole derivatives phenanthrenequinone was synthesized by using the above methord. Under the preferred reaction conditions, benzil, ammonium acetate, heterocyclic amino, aniline and m-nitrobenzaldehyde was subsequently used to synthesize 2-(m-nitrophenyl)-4,5-diphenyl-imidazole, 2-(m-nitrobenzaldehyde)-1, 4, 5-triphenyl imidazole, 2-(m-nitrobenzaldehyde)-4,5-diphenyl-1-(pyridiny-2)-imidazole, and 2-(m-nitrobenzaldehyde)-4,5-diphenyl-1-(thiazole-2)-imidazole. Phenanthrenequinone, ammonium acetate, amino heterocyclic, aniline and nitrobenzene formaldehyde was used to to synthesize 2-(m-nitrobenzaldehyde)-1-hydrogen-Philippine imidazole, 2(m-nitrobenzaldehyde)-1-pheny-1-hydrogen-Philippine-imidazole, 2(m-nitrobenzaldehyde)-1-(pyridiny-2)-1-hydrogen-Philippine-imidazole and 2(m-nitrobenzaldehyde)-1-(thiazole-2)-1-hydrogen-Philippine imidazole. Benzil, ammonium acetate, heterocyclic amino, aniline and p-nitrobenzaldehyde was subsequently used to synthesize 2-(p-nitrophenyl)-4,5-diphenyl-imidazole, 2-(p-nitrobenzaldehyde)-1, 4, 5-triphenyl imidazole, 2-(p-nitrobenzaldehyde)-4,5-diphenyl-1-(pyridiny-2)-imidazole, and 2-(p-nitrobenzaldehyde)-4,5-diphenyl-1-(thiazole-2)-imidazole derivatives. Phenanthrenequinone, ammonium acetate, amino heterocyclic, aniline and nitrobenzene formaldehyde was used to to synthesize 2-(p-nitrobenzaldehyde)-1-hydrogen-Philippine imidazole, 2(p-nitrobenzaldehyde)-1-pheny-1-hydrogen--Philippine imidazole, 2(p-nitrobenzaldehyde)-1-(pyridiny-2)-1-hydrogen-Philippine imidazole and 2(p-nitrobenzaldehyde)-1-(thiazole-2)-1-hydrogen-Philippine imidazole. The synthesized compounds were characterized and confirmed by IR, 1H NMR and carbon spectra.