Synthesis And Properties Of Acyloxy And Aryloxy Organotin Compounds

Organotin compounds are the important kinds of organometallic compounds, in the field of catalytic, thermal stability PVC, antiseptic, shipantifouling,it is widely used. Diversity and good anticancer activity structure makes it one of the focus areas of organometallic chemistry. In this paper, using solid-phase synthesis of grinding and solution we synthesis(21 kinds) new acyloxy and aryloxy organotin compounds.With elemental analysis, IR,H1 NMR, X- ray diffraction techniques we confirmed their structure and studied their interaction with DNA, proteins of biological macromolecules.Solid phase grinding method, insoluble in organic solvents on formyl benzoic acid and triphenyl tin hydroxide, Tricyclohexyl Fenbutatin tin hydroxide and tin oxide solid-phase reaction, then reacting with preparation of the formyl benzoyloxy tin porphyrin and synthesize pyrrole acyloxy tetraphenyl tin compound. By elemental analysis,IR, H1 NMR,we characterize their structure, with X- ray diffraction their crystal structure are detected which include four kinds of compounds, the results indicate that the carboxyl oxygen atoms coordinated with tin, Sn atom is five ligands, center Sn atom is trigonal bipyramidal configuration, where for formyl benzoyloxy triphenyltin(A1) forming a one-dimensional chain structure. And studying their interaction with DNA, proteins of biological macromolecules. DNA interaction with UV absorption spectrum show that tetrakis(4-formyl-phenyl) porphyrin triphenyltin acetate(B3) have a strong interaction with DNA at 20 ℃; fluorescence spectra shows, B3 of quenching way DNA-AO system for static quenching process. A1 and B3, respectively, bovine serum albumin(BSA) role, the fluorescence spectra shows, A1 BSA fluorescence quenching caused by the reason of static quenching, B3 is fluorescence quenching BSA with dynamic quenching.With the solvent method, functional groups containing a phenolic hydroxyl compound(3,5-dibromo-p-hydroxybenzaldehyde, 6-hydroxy-2-phenyl-3-pyridazinyl-one, 6-hydroxy-3-pyridazinone, 6- hydroxy-2-phenyl-3-benzo pyridazinone, 6- hydroxy-3-benzo pyridazinone, synthesis-hydroxyacetophenone, o-aminophenol) with an organic tin compound functions. With elemental analysis, IR, NMR,we characterize their structures, with X- ray single crystal diffraction determined the crystal structure of which 11 compounds, the results show that the oxygen atom and a tin atom phenolic hydroxyl group are bonded, 3 5 dibromo formylphenoxy triphenyltin(C1), 3,5 dibromo formylphenoxy tricyclohexyltin(C2), 2-phenyl-3-pyridazinone-6- group triphenyltin(D1), 2- phenyl-3-pyridazin-6-yloxy tricyclohexyltin(D2),3- pyridazin-6-yloxy triphenyltin(E1), on ethanone phenoxy triphenyltin(H1) forming a chain-like structure, with bit 5 Sn atom forming trigonal bipyramidal configuration, and D3、E3、 G3、H2、H3 of Sn atoms are 4 ligand, which is connected by hydrogen bonds between E3、G3、H3 in the molecular crystal structure. Further studying its interaction with DNA, proteins of biological macromolecules. Interaction with the ultraviolet absorption spectrum of DNA showe that, D3、E1 with increasing temperature, the binding constant increases, at 37 ℃, there is a strong interaction between the two compounds. C1 with increasing temperature, the binding constant decreases at 20 ℃, there is a strong interaction between the two compounds; fluorescence spectra shows, D3、C1、E1 for the DNA-AO system is dynamic quenching. Protein interactions result of fluorescence spectra shows, D3、E1 with BSA is dynamic quenching, and fluorescence quenching of BSA caused C1 for static quenching.