Construction Of Electrolytic Sustained - Release System Carrying Water - Soluble Drugs And Drug Release

Electrospinning is a novel and highly efficient polymer nanofiber fabrication process. The advantages of electrospinning as a fabrication process include adjustable process parameters, controlled production process, high raw material usage, simple and convenient operation, and reprodicible products which leads to its widespread usage. Fibers prepared by electrospinning can range from 2 nm to several μm in diameter. Nanofibers exhibit superior performance in many aspects, leading to their widespread usage in the biomedical field. In recent years, many researchers developed a variety of drug delivery systems, of which electrospinning controlled release is a novel method of controlled release. Highly soluble water-soluble drugs are rapidly absorbed and metabolised by the body, making it difficult to achieve long-term stable release, thus the drugs must be continually administered. In order to obtain ideal treatment effects, the electrospinning technique is a good solution to this problem. In current reports of electrospinning techniques that encapsulates drugs, emulsion electrispinning and coaxial electrospinning are widely used. However, coaxial electrospinning presents problems such as complicated parameter requirements in the spinning equipment, poor uniformity, spinning process unstable. Moreover emulsion electrospinning presents problems such as electrospinning solution instability and low efficiency of drug encapsulation. Thus, the construction of a stable, water-soluble drug-carrying electrospinning fibres has always been a challenge. In this thesis, we focus on current problems in electrospinning and controlled release of encapsulated drugs, and fabricate microsol electrospinning technique and nanogel electrospinning technique to create fibres that load, fix, and allow controlled-release of drugs.In the microsol electrospinning setup, first mechanical stirring is used to fabricate CQ drug-encapsulated HA microsol particles, which is stabilised and uniformly dissolved in PLLA electrospinning solution, then electrospun. In the latter part of the fibre characterization data, it can be that fibres fabircated using microsol electrospinning are smoother and more uniform on the surface, without obvious particles distributed on the surface. The fibre interior contains relatively uniform core-shell structure. The CQ drug-encapsulated HA hydrogel particles in the electrospun fibre memberane and the pure PLLA fiber membranes have similar physical, chemical, mechanical and other properties. It is obvious from the drug release profile that drug-carrying CQ microsol electrospun fibrous memberanes can obtain a relatively stable, long-term drug release process. Moreover, compared to coaxial electrospinning and emulsion electrospinning, the drug-carrying capacity of the fibres is higher, initial drug release is lower, drug release period is longer, and release mechanism can be controlled.In this thesis, the second half of the experiments constructs a nanogel electrospinning technology that has excellent stability and high drug-encapsulation efficiency. Through a temperature-controlled magnetic stirrer, BSA-encapsulated nanogel particle electrospinning solution was prepared and spun into fibres. It is clear from the latter fibre characterization data, BSA nanogel particles prepared by emulsion are uniform in size, fibre surface is smooth, and does not contain either hydrogel or drugs. Fibre interior obviously contains large amounts of encapsulated particles. From the in-vitro drug release profiles of nanogel electrospun fibrous membranes, one can see that initial CQ drug-loaded fibrous membranes allows for long-term stable release with high drug loading capacity, low initial drug release, and is tunable via drug concentration and BSA sol particle concentration to control drug release time and release rate.Thus, this thesis uses microgel and nanogel techniques to achieve efficient loading and controlled release of water-soluble drugs, creating a simple and highly efficient electrospinning technique to prepare a drug-loaded fibrous membrane with high efficiency in drug loading, low initial drug burst release, extended drug release period, and controllable and tunable drug release behavior, so as to develop a novel electrospinning fibrous membrane composite material to pioneer a new approach and provide a new method.