Measurement And Correlation Of Liquid-liquid Equilibria Of N-butanol—5-Hydroxymethylfurfural—wate R System And The Salting-out Effect

5-hydroxymethyl furfural(5-HMF) is an important biomass platform compound and a bridge substance between biomass and petrochemical industry. In recent years, a great attention has been paid to the preparation of 5-HMF from glucose using an aqueous two-phase solvent system. Therefore, it is significant to study the liquid-liquid phase equilibria of the relevant systems. In this work, the liquid-liquid equilibria concerned with the aqueous two-phase solvent systems consisting of n-butanol, water and salt Na Cl/KCl were investigated.Firstly, the liquid-liquid phase equilibrium data of a binary system(n-butanol+water), a ternary system(n-butanol+5-HMF+water) and two quaternary systems(n-butanol+5-HMF+Na Cl+water and n-butanol+ 5-HMF+KCl+water) at different temperatures were measured using liquid-liquid phase equilibrium cells. The compositions of both liquid phases were analyzed by using HPLC- UV method and potentiometric titration. The accuracy of the measurement was confirmed by comparing the experiment data of n-butanol+water with the ones in the literature.Secondly,The liquid-liquid phase equilibrium data of the binary system: n-butanol+water and the ternary system: n-butanol+5-HMF+ water are correlated using NRTL model by means of Aspen Plus software. It was shown that the calculation using NRTL model could reproduce the experiment data very well. The relative average deviation was within 1.3%.Finally, the salting-out effect were studied by comparing the equilibrium data of the non-electrolyte system with those of the electrolyte ones. With the increasing of the salt content, the partition coefficient of 5-HMF and n-butanol in the two aqueous phases increaseed significantly. Moreover, the salting-out effect of Na Cl was stronger than that of KCl.