Synthesis And Properties Of Metal Complexes Of Pyrimidine Derivatives

In this paper, we designed and synthesized three Pyrimidine ligands containing N atoms, 7-methylimidazo[1,2-a]-pyrimidine-2,5(1H,3H)-dione(Hmpd) and 2-(4-Hyd roxy-6-methylpyrimidin-2-ylthio)acetic acid(H2hta). Seven complexes have been synthesized by the reactions of three ligands and transition metals, namely, [Co(mpd)2(H2O)4]·2H2O(1), [Ni(mpd)2(H2O)4]·2H2O(2), [Co(hta)(H2O)3]·H2O(3), [Ni(hta)(H2O)3]·H2O(4), [Zn(hta)(H2O)3]·H2O(5), [Cu(Hhta)2(H2O)2]·3H2O(6), [Zn(hta)(bpy)2]·2H2O(7), [Co(hta)(bpy)2]·2H2O(8)(bpy=4,4’-bipyridine). All the complexes have been characterized by elemental analysis, X-ray crystallography, IR, 1H-NMR, PXRD and TGA. The properties of these complexes were investigated and discussed. In addition, the fluorescent, catalytic and antitumor properties of the complexes were also investigated.1. The ligands of Hmpd and H2 hta are characterized by IR and NMR. The single crystal X-ray crystallography of H2 hta shows 0 dimensional structure.2. Complexes 1-2 are obtained by the reaction of ligand Hmpd and transition metal salts Co(CH3COO)2·4H2O, Ni(CH3COO)2·4H2O through volatilization method. Complexes 3-6 are synthesized by volatilization of ligand H2 hta and transition metal salts Co(CH3COO)2·4H2O, Ni(CH3COO)2·4H2O, Zn(NO3)·2H2O, Cu Cl2·2H2O. Complexes 7-9 are obtained by the reaction of ligand H2 hta, 4,4’-bipyridine as auxiliary ligand and transition metal salts Zn(NO3)·2H2O, Co(CH3COO)2·4H2O, Cu(NO3)2·3H2O through volatilization method. In all complexes, the hydrogen bonds(H-bonds) are found to play an important role in their packing structures. Complex 1 and 2 are isomorphic, which show H-bonding 3D tfz-d topology. Complex 3-5 are also isomorphic, exhibiting an unreported H-bonding 3D topology. Complex 6 presents a H-bonding 3D new topology based on 14 H-bonds. {(H2O)4O2} H-bonding clusters in complex 7-9 link the coordination chains into a H-bonding 3D rtw topology.3. In addition, the catalytic properties of complex 1-4, 6-7 and antitumor properties of complex 6 are investigated. It is found that complex 1-4, 6-7 could catalyze the4. decolorization of methyl blue(MB) of 50%, 19.7%, 7.2%, 56.1%, 96%, 51.2%. 30%, 34%, 5%, 44%, 67.5%, 26.5 % of benzyl alcohol could be oxidized to benzaldehyde in presence of the complex 1-4, 6-7. Meanwhile, complex 6 shows 50.1% inhibition rate against Hep G2 cells growth.