Studies On The Stability Of Drug Suspensions

The purpose of this study is to establish an objective and precise evaluationmethodology of the stability of drug suspension based on the data and analysis resultsgained from the rapid characterization of the change on the stability of drugsuspensions by employing the multi light scattering theory and the relation betweenlight-intensity variation and particle movement.For this reason, there were a total of four compounds for active pharmaceuticalingredients and three macromolecule for suspensionsstabilizer adopted in the study.The four active pharmaceutical ingredients are Cimetidine, Furosemide, Nifedipineand Furazolidone, and the three macromolecule for suspensions stabilizer arepolyvinylpyrrolidone K30(PVP K30), hydroxypropyl methyl cellulose (HPMC) andpolyethylene glycol6000(PEG6000). By one-to-one matching each activepharmaceutical ingredient with each of the three stabilizers, a total of twelve drugsuspensions were eventually formulated under the given experimental conditions.The characterization through the Turbiscan disperse stability analysis instrumentwhich is based on the multi light scattering theory could facilitate the formulators togain the graphics of the light intensity variation of drug suspensions along the agingtime, the rules of its variation and the relevant data.. For all the four pharmaceuticalcompounds, it was found that the polymeric stabilizer PVP K30performed generallythe best for the effect of scatter and stability, and the rest two ones, which wereHPMC and PEG in sequence, followed after.The particle indication and the electrical indication demonstrated that thepharmaceutical particles sizes in the studied suspension systems ranged from enanometers to about microns; the stability of suspensions system was mainly due tothe special protection provided by stabilizer and the electrostatic repulsions betweenthe particles were too weak to bring sufficient strong interactions to support thesuspensions stability.The study results are thus meaningful to any similar drug suspensions formulation andthe design and optimization of drug suspensions systems.