Study On The Synthesis Of Cefoxitin Sodium And Stability

Cefoxitin sodium is developed by the U.S. Merck drug. The product is a broad spectrum antibiotic, has strong activity against Gram-positive bacteria, Gram-negative bacteria, anaerobic or aerobic, highly stable againstβ-lactamase, widely distributed in vivo, infection with high drug concentration in the exudates, mainly excreted by kidney, has less side effects and large tolerability.Cefoxitin sodium was introduced to Chinese market in 1992. In clinical applications, has been proved effective, side effects, low price. Other antimicrobial agents cannot match its advantage and it is worthy of wide application.Cefoxitin sodium current major domestic imported from Italy, the drug has been generally accepted by the domestic doctors, the current sales situation is better.To better meet the domestic demand for clinical treatment and reduce the burden on the people’s medication, the subject carried out the synthesis of sodium cefoxitin and stability study and quality control.Synthetic route has been reported mainly in five, the prevalence of synthetic routes: complex process, material special, low yield, high cost and other issues, not suitable for industrial mass production. Williamson reaction we used in the classic synthesis of 7-methoxy compounds; then 7-3-methoxy-acetyl compounds out of the base hydrolysis; Finally, chlorine isocyanate ammonia methoxy acid acylated by cefoxitin, and then Salt with sodium ethylhexanoate, obtained sodium cefoxitin. Yield of about 64.9%,99.9% purity.