Investigations On Properties Of Fluorescent Chemosensors For Zn²⁺ And Complexes With Schiff Base Ligands

In this thesis, a series of ligands with selective for Zn2+have been designed and synthesized, and the properties of fluorescent recognition toward metal ions have also been investigated in detail, respectively. In addition, we have synthesised a few Schiff bases bearing different arms based on salicylic aldehyde and their transition metal complexes, the different of their properties have been studied. The main contents can be presented as followed:In the first section, a brief review on the background of the research was concisely given; The mechanisms of chemical sensor and research progress of fluorescent sensors for metal ions were introduced; In addition, we especially focus on the classification of Zn2+fluorescent sensors and the related design principles.In the second chapter, we present a simple8-aminoquinoline-based fluorescence chemosensor with excellent fluorescence sensing ability to Zn2+over other cations. The sensor can coordinates to Zn2+and Cd2+via different binding mode, which lead to different spatial arrangement of the fluorogenic unit in these complexes. These results establish that the chemosensor can serve as a highly sensitive probe for distinguishing Zn2+from Cd2+. Furthermore, the fluorescence imaging of Zn2+in MCF-7cells was successfully obtained.In the third section, a series ligands of aminoquinoline with three arms what are benzyl amine, chaff amine and3-aminomethyl pyridine are synthesised. The influence of the different arms on me coordination chemistry properties and fluorescence properties was discussed in detail. The fluorescence responses of ligands to Zn2+shows that three ligands can serve as Zn2+chemosensor with high sensitivity and selectivity in HEPES buffer.In the fourth chapter, the design and synthesis of ligands based on Schiff base have been presented. The relationship between the structures, the properties of complexes and ligands, transition metal ions was studied. The fluorescence responses of ligands to Zn2+was also studied.