Advanced Primary Lung Yin Deficiency Syndrome Characteristics Inquiry

BackgroundPrimary lung cancer is among the most common clinical cancer and non-small cell lung cancer is the most common clinical lung cancer. More than half of them have been in the middle and late stage, with poor condition and prognosis, so many researches of modern medicine and Chinese medicine were carried out on non-small cell lung cancer. Chinese medicine in the treatment of advanced primary lung cancer has a unique advantage and so TCM pattern characteristics have been put on table now. TCM syndrome classification of lung cancer and quantitative criteria study has become the current trend. As a common pattern of advanced primary lung cancer, there is no study on Yin deficiency syndrome, no classification quantitative criteria or to evaluation of discourse, which is upset to the clinic need of the extent and effect of Yin deficiency syndrome.ObjectsThe research studied ancient texts on Yin deficiency, modern medical diagnostic criteria of Yin deficiency and list all diagnosis of all lung cancer. After the integration of clinical experts, we set up inclusion criteria for Yin deficiency syndrome. By collecting clinical cases, observing the patient basic condition,,. recording data and statistical analyzing related syndrome characteristics of yin deficiency of advanced primary lung cancer, we set up pattern points and diagnostics of Yin deficiency of advanced primary lung cancer and laid the foundation for the standardized diagnosis of Yin deficiency of advanced primary lung cancer and helped further quantitative studies, so as to the effect of TCM.Methods1. Develop group standards of Yin deficiency syndrome lung cancer. Through reading a lot of related academic writings, referring to prevailing authoritative national standards and combining clinical experience research supervisor Mr. Zhang Peitong, this issue proposed a criteria for diagnosing Yin deficiency syndrome lung cancer.2. Established inclusion and exclusion criteria and collected cases. Between July2013and August2013, we observed80patients with primary non-small cell lung cancer cases from Area11,15,19of CACMS Guang’anmen Hospital. In accordance with the inclusion criteria and exclusion criteria,33cases were Yin deficiency syndrome,47cases were non-Yin deficiency syndrome.3. Determined the clinical observation table after experts screened. Through a literature review, found out all clinical diagnostic criteria of Yin deficiency syndrome, merged duplicate items and deleted irrelevant items. Clinical experts finalize the11signs and symptoms as clinical observation projects.4Observe two groups patient’s age, gender, case, TNM stage, primary site, metastases, surgical cases, the degree of differentiation and KPS score, and the clinic projects of Yin deficiency group.5. Data recording and statistical analyzing:input the above surveyed items and data into Excel table; use the chi-square test by SPSS19.0to calculate clinical symptoms and signs with the Statistical differences between the two groups. Use the percentage of calculation method to count the existence proportion of clinical symptoms and signs in group of Yin deficiency syndrome. Find out the general clinical characteristics and initially establish Key points of the syndrome of Middle-advanced stage Yin deficiency syndrome lung cancer.ResultsIn this study, Yin deficiency syndrome group age range in all of the patients’ age is52-78. The average age of67.2years, median age was68years old. The non-Yin deficiency syndrome group age interval is48-81, the average age of65.8years, median age was68years old, the sample age into a normal distribution. Yin deficiency syndrome group has25males,8females, accounting for76%and24%. Non-deficiency syndrome group has31males and16females, each accounting for66%and34%, P>0.05, two groups have no significant difference in age. There are three pathological patterns in the sample, adenocarcinoma, squamous cell carcinoma and large cell carcinoma. With P>0.05, there is no significant difference in the two groups. Yin deficiency syndrome group has3persons with surgical removal of primary lung cancer lesions and30persons are not. The non-Yin deficiency syndrome group has11persons with surgical removal of primary lung cancer lesions and36persons are not. P>0.05, no significant differences in the two groups.Yin deficiency syndrome group differentiation of tumor cell differentiation from high, medium and low differentiation, followed by undifferentiated:0,6,23, and4cases. The Non-Yin deficiency group order:1,15,29,2cases. P>0.05, no statistical differences in the two groups. This study research patients with Middle-advanced stage lung cancer that TNM stages III, IV, P>0.05, no significant difference in the two groups. In the primary site of primary lung cancer, P>0.05, no significant difference in the two groups. In the metastatic sites, the test shows P>0.05, no significant difference in the two groups. The Yin deficiency group of patients followed Karnofsky score from100to60minutes, the test, P>0.05, in the two groups. Observe the distribution of yin deficiency symptoms, according to frequency of occurrence in the order of: cough without phlegm or less sputum, red tongue or no tongue, rapid pulse,hot and sweating, weight loss, five heart hot, dry mouth and throat, cold drink, hot flashes, dry stool, bloody and yellow urine.ConclusionIn this study, the Yin deficiency syndromes group and non-deficiency group has no significant difference on the patient’s age, gender, case, TNM stage, primary site, metastases, surgical cases, the degree of differentiation, KPS score (P>0.05). The number of patients included is not large, and cannot tell whether they are first visit or not. Before enter CACMS Guang’anmen Hospital, Some middle-advanced stage patients have accepted system treatment, such as Chemotherapy and surgery, and Chinese medicine treatment, so they generally turn for the better and have higher KPS score. The patients enter hospital without any system treatment score lower in KPS questionnaire. So KPS score cannot be good reference in this study, future studies should be conducted for a large sample of initial visiting patients with lung cancer without any treatment. This study summarizes the basic syndrome characteristics of middle-advanced stage non-small cell lung cancer of Yin deficiency syndrome, which cannot be universally generalized to all lung cancer patients of Yin deficiency syndrome.This research is only at the first stage of primary lung cancer of Yin deficiency syndromes. Because the sample size is small, patients’regionalism is not strong, experimental procedures is not meticulous enough detailed, and the diagnosis entries isn’t complete enough, this study failed to show the most comprehensive syndrome characteristics of Yin deficiency syndrome lung cancer. In future, larger scale and more scientific and effective quantitative criteria in the diagnosis should be carried out. Prospective epidemiological investigation and analysis of curative effect and Prognosis are also needed.