Clinical Efficacy Treatment Act Yishenhuoxue Extended Slow Progression Of Renal Failure, Renal Function Was Observed

Objective:The objectives of this study were to observe the clinical curative effect of delay the progression of chronic renal failure, using YI SHEN HUO XUE methods combine with treatment based on syndrome differentiation. To demonstration the TCM advantage to treat chronic renal failure.Methods:Collection50cases of chronic renal failure from china academy of Chinese medical science in WangJing hospital on January1,2012to December31,2013.Treatment with YI SHEN HUO XUE method combine with Western treatment basic for12weeks, test serum creatinine,urea nitrogen, glomerular filtration rate, hemoglobin, plasma albumin before and after treatment for4weeks and12weeks,test triglyceride, total cholesterol,24-hour urinary protein quantity, routine urine test before and after treatment12weeks. Observation TCM symptom score before and after treatment4weeks,12weeks, and analyze data. Evaluate the clinical effect of delay the progression of chronic renal failure, using YI SHEN HUO XUE method combine with treatment based on syndrome differentiation.Results:(1)The efficacy of the disease:the total effective rate was72%.The CKD3effective rate was78.2%,and CKD4effective rate was66.7%.The efficacy of CKD4is slightly lower than that of CKD3,howere,There was no statistical difference.There were no significant difference between the efficacy of elderly patients and non elderly group,male group and female group.It suggest that TCM can effectively delay the progress of renal failure,protect renal function.And the earlier treatment,the more likely reversal the renal function deterioration. This curative effect maybe independent of age.(2)The efficacy of TCM syndromes:total stabilizing effective rate is78.0%.The TCM clinical symptom scores after treatment4weeks and12weeks are significantly reduced than that before treatment(P<0.01). It shows that this method can obviously improve the symptoms of patients, improving the quality of life.(3)Laboratory indicators:After treatment4weeks and12weeks compared with before treatment, both serum creatinine and GFR were better than pretreatment, which serum creatinine significantly decreased and GFR significantly increased,and there was a signigicant difference(P<0.01).And this improvement was independent of age.It indicate that TCM can slow down the progression of renal failure development and protect renal function. There were no significant difference about BUN,ALB,HGB after treatment(P>0.05).CHO and TG were both better than before treatment, P<0.05,was statistically significant. It showed that TCM was beneficial for blood fat. For the before and after treatment12weeks comparison of 24-hour urinary protein quantity and proteinuria qualitative.the24-hour urinary protein quantity has statistically significant(P<0.01),and proteinuria qualitative has not statistically significant(P>0.05).It suggest that TCM reduced proteinuria to protect renal function. In addition,in the assessment of proteinuria,24hour urinary protein quantitative more accurate,urine protein qualitative may had some error.conclusion:YI SHEN HUO XUE methods combine with treatment based on syndrome differentiation can improve symptoms, improve the quality of life, decrease Scr, increase GFR, delay the progress of the renal failure, improve blood lipid and reduce proteinuria.This treatment was useful to renal in many ways.