Hypertensive Intracerebral Hemorrhage Therapy Clinical Study Program Promoting Blood Circulation

Objective:To observe the therapeutic effect of blood-activating and stasis-removing therapy on intracerebral hemorrhage. Observing the effect for modified Rankin scale score, Barthel score, the absorption of hematama and edema, NIHSS scale score and TCM syndrome score, in order to make the evaluation scientifically, objectively and systemically, and to provide new ideas on the treatment of cerebral hemorrhage.Method:To adopt the research method of a multi-center, prospective, randomized, controlled and blinded endpoint, we use center randomized method to implement the clinical grouping through SAS statistical software. The patients with cerebral hemorrhage(n=228) were randomly divided into the treatment group(n=114) and the control group(n=114). The control group was treated with the basic treatment of internal medicine. On the basis of it, the treatment group was received intravenous infusion with Xingnaojing Injection for2weeks and given TCM granules(wind syndrome, heat syndrome and phlegm) for21days dynamically and dialectically. After these, the treatment group was asked to drink Naoxueshu Oral Liquid untill the3rd month of incidence. To observe the curative effect in two groups and to evaluate the absorption of hematama and edema through head CT in1st and7th day. NIHSS scale score and clinical outcome assessment of patient reported stroke scale(PRO) were reviewed to evaluate nerve function defect and life quality in patients in1st,7th,14th,21st day and3rd month. To assess patients’ disability degree and daily living activity through modified Rankin scale and Barthel scale in21st day and3rd month.Results:12cases in treatment group and6cases in control group were eliminated and fallen off. There are no difference in aspect of age, sex, height, weight, temperature, disease course, blood pressure, hematoma position and volume, edema, NIHSS scale score, PRO score, modified Rankin scale score and Barthel(P>0.05). The total effective rate after three months in the treatment group was87.96%, in the treatment group was81.25%and had no significant difference(P>0.05).The modified Rankin scale score in treatment group is (1.25±1.441), obviously lower than that in the control group(1.88±1.338,P<0.01). Hematoma volume and edema area in7th day had no significant difference(P>0.05). However, there has a significant difference on the D-value of hematoma volume before and after treatment in two groups(P<0.05). The NIHSS Scale score of two groups in7th,14th,21thday and3rd month decreased significantly compared with that in initiation (P<0.05), and compared with control group, the score of treatment group is lower(P<0.05) in7th,21thday and3rd month. The Barthel scale score (89.12±19.9307) in treatment group was higher than that in control group (82.18±24.0256) after3months(P<0.01). The physiologic function, mentation, social relationship and treatment satisfaction of PRO scale scores in treatment group were all lower than the control group(P<0.05), and some single index in some time were also lower than the control group(P<0.05).Conclusion:Intracerebral hemorrhage with blood-activating and stasis-removing therapy had a effective result in improving hematoma absorption, neurologic function deficits and living ability in the3rd month. But the effect is not obvious in reducing edema area. And it also had a good result in reducing disability and fatality rate and increasing treatment satisfaction and life quality for patients. In addition, the adverse reaction was few and this scheme is effective.