Based Endogenous Collateral Wind Pathogenesis Theory Of Network Security Evaluation Value Dropping Pills

Objective:To investigate the value network of acute toxicological effects Luoheng pills evaluate its safety and to establish and improve safety evaluation of drugs before the drugs listed and not listed on the next development to provide a reference.Methods:①to "Articles Knowledge Service Platform Database " as search tools, retrieval and statistical analysis of clinical research literature on network safety evaluation scale domestic class parties2004-2014published. Results:Luoheng class party network by searching (Luoheng Fang, Luoheng pills, Luoheng the1st party) safety evaluation of clinical research literature19, which accounted for more than half of the clinical trials, review, retrospective studies and literature measured separately accounted for, very few prospective follow-up study, the sample size in the following experiments all500cases, the small sample size, no large-scale clinical applications. Evaluation of the main94.1%of medical institutions, focused on the evaluation of network objects weighing pi11s, simple little literature discussing adverse react ions.②Acute toxicity test:(1) take60mice, weighing20±3g, male and female, were randomly divided into three groups, namely, network scale Luoheng Pills high-dose group (maximum concentration of the drug in this experiment was100%, lml dissolved in distilled water up to12bags of the powder. conventional mice administered0.4ml/10g), low-dose group (1/2high-dose group), distilled water groups of20. Gavage doses of contact to the appropriate balance pills, low-dose group1times/day, high-dose group2times/day, continuous observation of14days and calculate the total dose, and calculate the amount equivalent to a multiple of clinical medicine. Animals were observed for mortality, and determine the cause of death, and pathological examination, a clear maximum dose of the drug tested.Results:①The number of network safe y evaluation of clinical literature studies class Luoheng though increasing year by year, but the quality is uneven, evaluation methods and experimental design most of the literature is not yet standardized, science needs met technical specifications, quality control evaluation, multi-agency cooperation to establish and improve the safety evaluation has not been marketed drugs and medicines before the next development to provide a reference listed.②Network Luoheng Pills acute toxicity value was not found pathological changes in various systems of test mice, the highest dose group was found five cases of death, after discussions with the experimental considered improper operation or administered overdose related. All surviving mice found that the appearance of the experimental observation of signs, behavior, eating, weight, stool no obvious abnormalities. The organ pathology, no obvious abnormalities. Contact Heng dropping pills showed no acute toxicity, when the maximum daily dose within4.67g/kg, the clinical use is safe.Conclusion:Acute toxicity dropping pills network scale experiments suggest no acute toxic effects.