| With the alcohol consumption increasing, the attack of alcoholism has been appeared toascend. Excessive ingestion of alcohol, especially strong drink, can not only bring aboutdamages to center neural system, digestive system, circular system, and so on, but also canendanger stabilization of family and society. Alcoholism has been a serious problem ofsanitation and society. Acai (acai) is a berry grown on the acai palm tree (Euterpe oleracea), which is native to tropical Central and South America and grows mainly in floodplains and swamps. In2013the Ministry of Health approved acai (acai) entering the country as a new source of food.A brief review of acai (Euterpe Oleraceae Mart.) in the scientific literature.In recent times, research on Acai fruit has centered on its potential antioxidant properties. In laboratory research, Acai has alsodisplayed anticancerand anti-inflammatory activity, possibly related to its antioxidant content.Proanthocyanidins have also been isolated from Acai extracts. Flavonoid-like compounds, including homoorientin, orientin, taxifolin deoxyhexose, isovitexin, and scoparin, have been identified. Protocatechuic acid and epicatechin (a polyphenol) have beenidentified as minor compounds. Acai has received much attention in recent years due to potential health benefits.Acai is a plant having medicine and food function in Amazon region with a great economical value and developing prospect.Alcoholic liver disease is a common clinical disease, caused by long-termalcohol abuse. Although modern medicine are recognizing and researching ALD deeply, the therapeutic tool islimited, it is short of drugs which is safe and effective. How to develop medicine and health products using plant resources has received much attention in recent years.The result of analysis is that the pathogenesis of ALD results from the mutual contention of qi,blood, phlegm and dampness. Fortifing the spleen and soothingliver, regulating qi and activating blood and resolving phlegm and dispelling dampness is the main treating method. We should reinforce the healthy qi in the advanced stage due to exuberance of pathogen with decline of the healthy qi. Blood-activating and stasis-resolving medicina, dampness-draining diuretic medicinal medicine.dampness-resolving and qi-moving medicinal are common treating.This study was designed to explore the protective effect of acai against alcohol liver injury and the mechanism. Summarized the nature of Aaci with Scientific literature and traditional Chinese philosophical thought. This study take advantage of the Features and Benefits of Clinical Chinese Herbs Medicine, enrich the Research contents and Contribute to the development of disciplines. The indieators and results of this study include the following aspects:1The detoxification effect of acai against acute alcohol toxication1.1The detoxification effect of acai against acute alcohol toxication and the impact on the ethanol concentration in miceObjective:We researched on the detoxification and mechanism of Acai. Methods:We observed the disappearing and recovery time of righting reflex of mice. Results:Acai can shorten the recovery time of righting reflex(P<0.05). Conclusions: Acai has the effect of detoxification.1.2The detoxification effect of acai against acute alcohol toxication and the impact on the ethanol concentration in miceObjective: To investigate the effects of Acai on acute Ethanol induced spontaneous activity.Methods: Locomotor activity was detected to observe the effect of Acai on Ethanol induced spontaneous activity after administration of EtOH.Result:The groups of Acai significantly reduced the amount of spontaneous activity (P<0.01) which were induced by ethanol.Conclusions:Acai has the effect of reducing amount of spontaneous locomotion activity caused by excitement of central neural system.1.3The detoxification effect of acai against acute alcohol toxication and the impact on coordination of miceObjective: To observe the effect of coordination of mice. Methods: Coordination were tested with sloping panel.Recorded the falling times of mice from the sloping panel. Results: Acai group couldsignificantly decreased the falling times of mice on sloping panel (P<0.05). Conclusion:Acai can obviously improve the mouse movement coordination ability.1.4The detoxification effect of acai against acute alcohol toxication and the impact i on leaming and memory abilities.Objective: To study the effects of Acai on leaming and memory abilities.Methods: The step-down test were adopted.Results:The results indicated that Acai dependently improved the impairment of memory acquisition, memory retrieval induced alcohol in mice.Conclusion: Acai can improve memory retrieval induced by alcohol in mice.1.5The detoxification effect of acai against acute alcohol toxication and the impact on the ethanol concentration in miceObjective:We researched on the detoxification and mechanism Acai. Methods: We observed serum ethanol concentration of mice. Results:Acai group has the tend of reduceing serum ethanol content but without significant. Conclusions:The groups of Acai has the effect of detoxification, but has no impact on serum ethanol concentration. 1.6The detoxification effect of acai against acute alcohol toxication and the impact on the alcohol in mice dehydrogenaseaObjective:We researched on the detoxification and mechanism Acai. Methods:We determined the changes in activity of Alcohol dehydrogenase (ADH) in liver of mice. Results: Acai group has the tend of improveing ADH activity in liver but without significant. Conclusions:The groups of Acai has the effect of detoxification, but has no impact on the alcohol dehydrogenase (ADH) activity.1.7The protective effect of acai against acute alcohol toxication and acute alcohol liver injury in miceObjective:To study the effects of Acai on acute alcohol toxication and protective effect on acute alcohol liver injury in mice. Methods:Acute alcohol toxication animal model was established by alcohol gavaged (50%at15mL/kg). The acute liver injury animal model was established by alcohol gavaged (50%at12mL/kg). The serum levels of ALT, AST and the content of MDA, TG, the activity of GSH, SOD in liver of the mice were measured. Results: The sleep latency were significant different compared with the model group (P<0.05). The group of Acai significantly reduced the levels of serum ALT, AST(P<0.01) which were induced by ethanol, and the content of MDA, TG (P<0.05), the activity of GSH in liver were significant different compared with the model group (P<0.05). Conclusion: The results indicated that Acai has effect of relieving alcohol toxicity and had a protective effect on acute alcohol liver injury in mice and the mechanism of it may relate to the capacity of anti-oxidant.2The protective effect of acai against acute alcohol liver injury in rat and the mechanism of anti-oxidant2.1The protective effect of acai against acute alcohol liver injury in rat and the mechanism of anti-oxidantObjective:To study the protective effect of Acai on acute alcohol liver injury In Rat. Methods:The acute liver injury animal model was established by alcohol gavaged (50%at12mL/kg). The serum levels of ALT and AST and the content of MDA, TG, the activity of GSH, SOD in liver of the Rat were measured. Results: The groups of Acai significantly reduced the levels of serum ALT, AST(P<0.01) which were induced by ethanol, and the content of MDA, TG (P<0.05), the activity of GSH in liver were significant different compared with the model group (P<0.05). Conclusion: The results indicated that Acai had a protective effect on acute alcohol liver injury in Rat and the mechanism of it may relate to the capacity of anti-oxidant.3The Protective Effect of Acai against on chronic alcoholic hepatic injury in rats3.1The Protective Effect of Acai against on chronic alcoholic hepatic injury in rats Objective: To study the protective effect of Acai on chronic alcoholic hepatic injury in rats and its mechanism. Methods: The chronic hepatic injury model was established by intragastrically administered with gradient alcohol for8weeks. The serum levels of ALT, AST, and the content of MDA, TG, the activity of GSH, SOD in liver of the Rat were measured. Results:The groups of Acai significantly reduced the levels of serum ALT, AST (P<0.05) which were induced by ethanol, and the content of MDA, TG (P<0.05), the activity of SOD in liver were significant different compared with the model group (P<0.05). According to liver histopathological observation, most structures of hepatic lobules in the model group were destroyed, with diffuse fat empty bubbles of different sizes in cytoplasm,focal necrosis and infiltration of inflammatory cells. All of treatment groups showed alleviation in rat liver injury to varying degrees.Conclusion: The results indicated that Acai had a protective effect on alcohol liver injury in Rat and the mechanism of it may relate to the anti-oxidant effects.4The Protective Effect of Acai against Acute Alcohol liver Injury In Rat and the Mechanism of Anti-oxidant4.1The protective effect of Acai against on chronic alcoholic hepatic injury in rats and its mechanism.Objective:To study the protective effect of Acai on chronic alcoholic hepatic injury in rats and its mechanism. Methods: The chronic hepatic injury model was established by intragastrically administered with gradient alcohol for8weeks. The serum levels of TNF-α TGF-β1、IL-6、IL-8were measured. Results: The groups of Acai significantly reduced the levels of serum TNF-α(P<0.01,0.05)、TGF-β1(P<0.01,P<0.05,P<0.01)、IL-6(P<0.05) and IL-8(P<0.01) which were induced by ethanol. Conclusion: The results indicated that Acai had a protective effect on alcohol liver injury in rats and the mechanism of it may relate to the anti-inflammatory and anti-oxidant effects.4.2The Protective Effect of Acai against on chronic alcoholic hepatic injury in ratsObjective:To study the protective effect of Acai on chronic alcoholic hepatic injury in rats and its mechanism. Methods: The chronic hepatic injury model was established by intragastrically administered with gradient alcohol for8weeks. Liver tissues were collected to dectect the pachological alteration HE staining, the protein expressions of CD68were determined with immuniochemistry. Results: the protein expressions of CD68which were induced by ethanol, Compared with alcohol, the group of Acai significantly down-regulated hepatic TGF-β1,CD68mRNA transcription(P<0.01) Conclusion: The results indicated that Acai had a protective effect on alcohol liver injury in Rat and the mechanism of it may relate to the anti-inflammatory effects. 4.3The Protective Effect of Acai against on chronic alcoholic hepatic injury in ratsObjective: To study the protective effect of Acai on chronic alcoholic hepatic injury in rats and its mechanism. Methods: The chronic hepatic injury model was established by intragastrically administered with gradient alcohol for8weeks. The mRNA expression of genes(NRF-2、NF-κB TGF-β1. CD68) in hepatic tissue were tested using real time RT-PCR. Results:. Compared with alcohol, the group of Acai significantly down-regulated hepatic Nrf-2mRNA transcription(P<0.01), significantly up-regulated hepatic NF-κB mRNA transcription(P<0.05). Compared with alcohol, the group of Acai significantly down-regulated hepatic TGF-β1,CD68mRNA transcrip ion(P<0.01).Conclusion: The results indicated that Acai had a protective effect on alcohol liver injury in rats and the mechanism of it may relate to the anti-inflammatory and anti-oxidant effects.4.4Effect of Acai on monoamine neurotransmitter of hippocampal tissue in alcoholisim ratsObjective: To study the effect of Acai on monoamine transmitters and their metabolites of hippocampal tissue in alcoholisim rats. Methods: The chronic hepatic injury model was established by intragastrically administered with gradient alcohol for8weeks. After eight weeks, hippocampus were rapidly removed and frozen immediately, the contents of5-HT of hippocampal tissue in alcoholism rats were deteeted by radiolnlnunoassay.Results: Compared with normal group, the contents of5-HT of hippocampal tissue increased in model group, there is significant difference. Conclusion: These results suggest that alcohol may affect the metabolism of monoamine neurotransmitters, but we need futher research to prove it.We observed Acai curative effect onprevention of drunkenness through animal experiments.After duplicating the animal modelsof acute alcoholism, we studied influence of Acai on the lethargic time, spontaneous locomotion activity, study and memory test, the balance of act, and metabolism of alcohol of acute alcoholic mouse.We get the following results:Acai can resist the depression of alcohol on centralneural system, which is shown by shortening the sleeping time, reducing amount ofspontaneous locomotion activity caused by excitement of central neural system, improving theataxia and improving study and memory of mice.It has no effect on alcohol concentration inblood effectively and the activity of alcohol dehydrogenase (ADH) in the liver.In acute and chronic alcoholic hepatic injury, Acai do have the protective effect, Mechanism of it may related to antioxidant properties, and anti-inflammatory activity.5Study on Acai of nature of Chinese Herbal MedicineThis study explored the protective effect of acai against alcohol liver injury and the mechanism.Summarized the nature of Aaci with Scientific literature and traditional Chinese philosophical thought. This study enlarging the clinical application of Acai, providing reference for the clinical usage of Acai reasonably, safely and efficiently. This study take advantage of the Features and Benefits of Clinical Chinese Herbs Medicine, enrich the Research contents and Contribute to the development of disciplines5The nature of Acai summaryThis paper study on acai from the nature of Chinese herbal medicine based on the existing scientific literature and our study, traditional Chinese philosophical thought and modern scientific methods.The attribute of Chinese Traditional Medicine, cold, hot, warm and cool, is mainly obtained through change of symptoms and signs of the invalid organism or normal body. Acai has displayed anti-oxidant and anti-inflammatory activity.Proanthocyanidins have also been isolated from Acai extracts. Flavonoid-like compounds, including homoorientin,orientin, taxifolin deoxyhexose, isovitexin, and scoparin, have been identified. Protocatechuic acid and epicatechin (a polyphenol) have beenidentified as minor compounds. Acai has been a traditional food of the natives of the Amazon for hundreds of years.Most of food belongs to the peaceful property of drug.Therefore, The attribute of Acai is some cool.Five Flavours (pungent, sweet, sour, bitter, and salty),is knownand by taste firstly and modified via clinical practice. Chinese Herbs with sour characteristic usually have the hypolipidemic, antidiabetic and liver protective effects.The taste of Acai is sour and has the effects of hypolipidemic, antidiabetic and liver protection. Chinese Herbs with sour characteristic usually has carbohydrates, proteins, amino acids,usually used as supplementary nutrition wich can improve immunity and modulate immune function. Acai has displayed anti-oxidant and anti-inflammatory activity. Flavonoid-like compounds isolated from Acaiincluding homoorientin, orientin, taxifolin deoxyhexose, isovitexin, and scoparin. Acai has displayed anti-oxidant, anti-inflammatory activity and modulate immune function, possibly related to its antioxidant content. Acai has been a traditional food of the natives of the Amazon for hundreds of years.Therefore, The taste of Acai is sweet and has the effects of supplementing Qi and nourishing Yin and anti-Diabetes.Tropism application in clinical traditional Chinese medicine, related to disease location in clinic. Acai has been a traditional food of the natives of the Amazon for hundreds of years. Some drugd with homo logy of medicine and food characteristic enter the meridians of spleen and stomach. Such as Glycyrrhiza, Chinese Yam, Jujube, etc. Alcoholic liver disease is caused by long-termalcohol abuse, coused spleen and stomach injury. Some Chinese Medicine with detoxification effect Such as Flos Puerariae, and Hovenia Dulcis Thunb also enter the meridians of spleen and stomach. It can be inferred that Acai enters the meridians of spleen and stomach.After a number of food safety evaluation the new resources can be approved, It complies with food standards, Acai is non-toxic.In conclusion, Acai is some cool and sour and sweetin flavour, no toxin and enters spleen and stomach meridian. Acai has hypolipidemic, antidiabetic and liver protection effects, it can supply Qi and nourishing Yin.In summary,This study take advantage of the Features and Benefits of Clinical Chinese Herbs Medicine, enrich the Research contents and Contribute to the development of disciplines. |
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