General Hospital Antifungal Use Analysis Of The Situation And Fungal Infection In Clinical Epidemiology

Objective To study the usage of Antifungal drugs and the epidemiology of deep fungal infection. Methods A retrospective analysis was carried out on medical records of our hospital from February2011to May2011.We collected information of cases which used anti-fungal agents and had deep fungal infections. Then analyzed the information and did a summary. Results1. Retrospectively analyzed22185cases.There was221cases of them used fungal agents accounting for about1%.2. The usage of antifungal agents firstly gave to targeted therapy, accounting for62.90%. preventive treatment was only37.10%.3. The medication alone was the uppermost for anti-fungal drug using(85.07%).4. The main type of clinical anti-fungal agents were fluconazole (60.18%) and voriconazole (46.61%).4.There was139cases of22,185cases which were regarded as deep fungal infection, accounting for0.63%of the total number. There were12cases confirmed diagnosis,52cases of clinical diagnosis and75cases suspecting diagnosed.5. Deep fungal infection occurred mainly in patients over60years old (58.27%). The department of respiratory (36.69%) is the most common department for deep nosocomial fungal infection.6. Parts of deep fungal infection gave first place to the lungs(69.06%) and mouth(14.39%). Fungus inspection for sputum specimens were most positive (62.69). Candida albicans (64.77%) is still the main pathogen of deep fungal infection in our hospital.7. The major risk factor of deep fungus infection in hospital were using of broad-spectrum antibiotics (69.78%, system glucocorticoid (51.80%, immunosuppressive agents and chemotherapy drugs (30.22%). Conclusion1.The mainly use of antifungal drugs in our hospital was for target therapy, combination and alternation using were less. Majority of patients had good prognosis.2. Fluconazole and voriconazole was the most used antifungal drugs.3. The diagnosis level of deep fungal infection is suspecting diagnosis, followed by clinical diagnosis. The rate of confirmed case was only accounting for8.63%. Doctors should paid more attention to pathogenic examination for deep fungal infection.4. Most deep fungal infection cases in the department of respiratory, the department of hematology and intensive care unit. These departments should pay more attention to prevention and treatment of fungal infection.5. The main pathogens of deep fungal infection were candida albicans.6. Long-term using of antibiotics, glucocorticoid, immunosuppressants, chemotherapy drugs and older age is the risk fector of deep fungal infection.