Spectral Characteristics And Theoretical Studies Of Basal Cell Carcinoma

Spectroscopy as a non-invasive measurement, make in vivo fast nondestructive testing come true. Diffuse reflection spectra and fluorescence spectra were used to study the optical properties of Basal Cell Carcinoma, the effect of blood content on cancerous skin were also considered theoretically. First of all, a brief introduction of the study history on spectroscopy used in the diagnosis of skin diseases outlines the current situation and progress of Basal Cell Carcinoma at home and abroad. The skin structure and common skin disease were introduced briefly. Secondly, the principle of spectral technology and its application in medical field were outlines in detail. Introduce the transmission theory and the use of Monte Carlo simulation. Afterwards, based on the microscopic autofluorescence image and the seven-layer normal skin optical model advanced by Prof. Zeng, we optimized an eight-layered optical model of Basal Cell Carcinoma skin. By Monte Carlo simulation, the light distribution, the diffuse reflectance and fluorescence were calculated in visible wavelength range to compare with the experimental results. Finally, two different blood contents were added to the BCC layer in the optical model, the contribution of blood on diffuse reflectance and fluorescence spectra were investigated by Monte Carlo theoretically. The spectra calculated by Monte Carlo simulation agree with the experimental result in general.Our work provides a practical theoretical method to study the transmission process of intrinsic autofluorescence. The eight-layer Basal Cell Carcinoma skin optical model, the method of modifying blood content in the optical model, and Mont Carlo simulation method may also be useful for other cancer skin studies.