18F-FDG And18F-FLT PET/CT Guided Dose Painting For Patients With Non-small Cell Lung Cancer In Radiotherapy

[Background]Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting---a new RT strategy delivering optimized dose redistribution according to the functional imaging information to further improve tumor control. A homogeneous boost dose is assigned to the subvolume contoured by a threshold created in PET images in dose painting. The new combination will revolutionise the way that RT is prescribed and planned and may improve the therapeutic outcome in terms of local regional control.[Objectives]The aim of the present study was to compare FLT and FDG PET/CT guided dose painting plannings with CT guided radiotherapy plannings in patient with non-small cell lung cancer.[Methods]We choose paitients with FLT and FDG PET/CT in the same day, then contoured the ROI with higher than50%SUVmax in FDG PET/CT and80%SUVmax in FLT PET/CT. Then we use the confused imaging of both ROIs as the sub-volume to boost. We compared the FLT and FDG PET/CT guided dose painting plannings with CT guided radiotherapy plannings.[Results]The maximum dose of the targets FLT and FDG PET/CT guided dose painting planning is higher than CT guided radiotherapy planning by an escalation of15Gy、 12.5Gy、31.35Gy、19.8Gy、12.8Gy.The OAR is under the common dose constraint.[Conclusions]The maximum dose of the subvolume contoured by18F-FLT and18F-FDG PET/CT imagings is higher than CT guided radiotherapy planning with constant burden of the normal tissues.