The Study Of Prevalence And Risk Factors Of Ckd Among The Adults With Low Cardiovascular Risk Factors

Backgroud and objectivesChronic kidney disease (CKD) has been a global public health problem seriously affected human health and provided high burden to society. According to the recent national survey, the prevalence of CKD is10.8%in China, and the total number of Chinese living with CKD is now estimated to be119.5million. A clinical practice guideline from the American College of Physicians recommends against screening for chronic kidney disease in asymptomatic adults with low risk factors for chronic kidney disease. However, as the disease patterns, ethnic composition and lifestyle in China are significantly different with the American’s, the prevalence and risk factors may have difference too. In this study we aimed to explore the prevalence and risk of CKD among the adult population with low cardiovascular disease (CVD) risk factors.MethodsThe adults visited the Health Checkup Clinic consecutively from January2012to May2013were enrolled in the study. CKD was defined as decreased estimated glomerular filtration rate (eGFR<60ml/min·1.73m2) or the presence of albuminuria (urinary albumin-to-creatinine≥30mg/g). Four CVD risk factors were defined as one or more of the following:hypertension, diabetes, dyslipidemia and overweight.ResultsAmong the total899partipants in this study, the prevalence of CKD was5.1%(95%CI3.7%～6.6%), hematuria6.5%(95%CI4.8%～8.1%), proteinuria4.1%(95%CI2.8%～5.4%), and reduced eGFR1%(95%CI0.4%～1.7%). The binary logistic regression analysis showed that except gender, the other factors such as age, smoking, drinking, HbsAg and chronic respiratory infection were all not associated with CKD among adults with low CVD risk factors.(P>0.05).Conclusions1. The prevalence of CKD was5.1%in adults with low CVD risk factors visited the Health Checkup Clinic. In the low CVD risk factors populations, CKD, albumuria or reduced eGFR has no association with age, smoking, drinking, HbsAg and chronic respiratory infection, but female is the independent risk factor of CKD and albuminuria.2. Even in populations with low cardiovascular disease risk factors, screening for CKD is still necessary considering the high prevalence and harms of it.