Clinical Analysis Of Recurrence Related Factors In47Cases Of Primary Liver Cancer After Liver Transplantation

IntroductionAnalysis of cases who accepted transplantation for primary liver cancer in our department from January1,2005to December30,2013to explore the related factors influencing the postoperative tumor recurrence, consequently providing reference for clinical treatment.MethodsA retrospective study was conducted in47cases of patients who accepted transplantation for primary liver cancer from January1,2005to December30,2013. exclude deaths in5days after operation and those with incomplete medical records. According to the postoperative recurrence of tumor, participants were divided into relapse group and control group,. We selected possible influencing factors by looking up literatures and clinical experience, and statistical analysis was conducted.ResultsIn the47participants (42male and5female) aging from33to66, there were16cases with postoperative recurrence (14male and2female). The prevalence in total was34%, among men was33%and among women was40%. Single factor statistical analysis demonstrated that age, sex, treatment before operation,HBV、HCV infection, Child grading and tumor number had no statistical significance; while size of the tumor(p=0.0184), vascular invasion (p=0.0047), tumor TNM (UICC) staging (p=0.0210), Hangzhou standard (P=0.0036), preoperative AFP level (p=0.009), were statistically significant, especially Hangzhou standard.ConclusionsCancer recurrence has been a huge challenge to liver transplantation. The clinical data show that the turner size (≥5cm), the vascular invasion, the tumor TNM staging, the Hangzhou standards and the AFP levels of preoperation are risk factors for recurrence of primary liver cancer after liver transplantation. The indications of liver transplantation should be strictly controlled. If it beyonds the Hongzhou standards, the liver transplantation should be avoided because of the higher cancer recurrence rates. If the AFP levels greater than400ng/l, or the tumor size greater than5cm, or with the vascular invasion, we can take some measures to introduce the recurrence of tumor. For example, we should carefully surgery to make sure that the vascular thrombosis must be taken clean. After operation, patients should be regular in AFP and imaging. In sometimes, preventive chemotherapy is necessary to reduce the risk of tumor recurrence.