Prognostic Impact Of Fragmented QRS In Patients With Chronic Heart Failure

Background:Sudden cardiac death (sudden cardiac death, SCD) is one of the leading causes of death among patients with cardiovascular disease. Risk stratification of sudden cardiac death (SCD) is important in clinical.Scholars found that f-QRS were associated with increased mortality and arrhythmic events in coronary artery disease(CAD) Patients, f-QRS have also been defined as a predictor of arrhythmic events in patients with cardiomyopathy. fQRS was also a predictor of mortality and the lethal arrhythmic events in nonischemic dilated Cardiomyopathy patients.Relatively little data are available regarding prognostic impact of fragmented QRS(fQRS)in patients with chronic heart failure(CHF).Objective:To discuss the prognostic impact of fragmented QRS(fQRS)in patients with chronic heart failure(CHF).Methods:Dates from patients with CHF admitted between January2010to December2012were analyzed retrospectively. The study population were divided into two groups by whether the f-QRS take place on12-lead electrocardiograph or not which are named f-QRS or no-fQRS group respectively. The primary clinical end point is all-cause mortality; the second end points are combined with all-cause mortality and rehospitalization for heart diseases.Results:The mean duration of follow-up was26.25±10.87months. The number of patients in f-QRS group are172with458patients in no-fQRS group. As a result of multivariate Cox proportional hazard analysis, fQRS was not associated with a rise of all-cause mortality(RR1.03;95%CI0.95-1.11; P=0.47). The second end point of was higher in the f-QRS groups versus no-fQRS group (RR0.69;95%CI,0.65-0.74; P<0.01). The appearance of f-QRS was significantly correlated with the presence of ventricular tachycardia and fibrillation in-hospitalized patients(R=0.358, P<0.001).Conclusion:In CHF patients, the presence of fragmented QRS is not associated with a higher risk of death from all or arrhythmic lonely. f-QRS is a valuable factor to predict all-cause mortality and rehospitalization for heart disease, and it is significantly positive correlation with ventricular tachycardia or fibrillation taking place in hospital too.