Effect Of Paishi Decoction On The Bile Compositions Of Common Bile Duct Calculi Post-ERCP Patient

Background:A common bile duct calculus was a common and frequent disease. The therapeutic treatment for this disease was reported to be good therapeutic effect on removing stones, but with difficulty in removing residual stone and its high rates of recurrence. Traditional Chinese medicine was reported to be the good therapeutic effect on eliminating jaundice and residual stone, and to prevent recurrence of stones in some ways. It was requested to found one effective method of treatment and prevention of common bile duct calculi with ERCP combined traditional Chinese medicine. Therefore, this experiment was designed based on it.Objective:To study the effects of paishi decoction on the bile compositions of common bile duct calculi post-ERCP patient.Methods:Eighty-eight patients with common bile duct calculi were randomly assigned to the control group and the experimental groups dividing them into one high-does group and another low-does group for traditional Chinese medicine. The control group patients underwent the ERCP and the experimental group patients took the treatment of ERCP combined traditional Chinese medicine lasting4days after24hours post-ERCP. The bile drained from ENBD during the first post-ERCP day and the fifth post-ERCP days were examined. The contents of total bile acids, total cholesterol, direct bilirubin, indirect bilirubin, calcium ion and mucin were detected and compared.Results:①Four days after taking paishi decoction in the experimental groups, the total bile acids increased, the total cholesterol, direct bilirubin, indirect bilirubin, calcium ion and mucin decreased, showing statistically significant difference when compared with the same group for the first post-ERCP day (P<0.05).②There were no statistically significant difference in the level of direct bilirubin and mucin in the control group for the fifth post-ERCP day when compared with that for the first post-ERCP day (P>0.05), reaching statistical difference in the level of the total bile acids, the total cholesterol, indirect bilirubin and calcium ion(P≤0.05);③The level of direct bilirubin changed after taking paishi decoction in the low-does group only, comparing with the control group, was statistical difference (P≤0.05), with the others in the low-does and all those of bile compositions in high-does group having no significant change(P>0.05);④The level of total bile acids, total cholesterol, direct bilirubin, indirect bilirubin, calcium ion and mucin in the low-does group showed no statistically significant difference when compared with the high-does group after the treatment of paishi decoction (P>0.05). Conclusion:Paishi decoction could partly improve pathologic bile compositions of common bile duct calculi after taking it a short time post-ERCP and improve the environment of the biliary tract, having therapeutic effect on removing residual stone and certainly preventive and therapeutic effects on bile duct calculus.