Gd-EOB-DTPA Enhanced MRI In Quantitative Evaluation Of Liver Function

Objective:To explore the value of Gd-EOB-DTPA enhanced magnetic resonance imaging(MRI) in the quantitative evaluation of liver function.Methods:Between September2011and September2013, we prospectively included patients with cirrhosis and primary hepatic carcinoma(PHC). We divided Simple cirrhosis patients into group A and PHC into group B. All patients were scored of Child-Pugh classification in preoperative and postoperative of24hours.ICG R15and Gd-EOB-DTPA enhanced MR imaging were performed in all patients. Used high pressure syringe to inject contrast medium through the elbow vein. Enhanced MRI sequence:TR/TE3.92/1.39msec, FOV=380mm×309mm, matrix=364×640. In liver phase image,we collected the signal strength with the application software, and then got the time-intensity curves at the abdominal aorta and the liver parenchyma. Deconvolution analysis of the aortic and hepatic parenchymal time-intensity curves was performed with Fourier transform technique. The correlation between HEF and Child-Pugh and ICG R15were analyzed.Results:1. In group A, there were4cases of Child-pugh A, and4of Child-pugh B; In group B,5cases of Child-pugh A, and lcases of Child-pugh B.2. The average ICG R15of group A was(13.99±3.65)%, group B was(9.67±2.60)%.3. The average HEF of group A was (80.51±7.77)%, group B was (87.01±8.10)%.4. There was a significant correlation between the HEF and ICG R15by the Pearson correlation coefficient assessment of group A (γ=-0.971, P=0.000)and group B(γ=-0.855,P=0.030).5. There were still4cases of Child-Pugh A after operation, the preoperative HEF was (89.83±3.47)%, and4cases into Child-Pugh B, the preoperative HEF was (83.75±2.19)%;4cases of Child-Pugh B after operation, and the preoperative corresponding HEF was (75.63±4.01)%, and1cases into Child-Pugh C, the preoperative corresponding HEF was70.80%.6. The HEF of hepatic carcinoma tissue was (25.65±6.98)%。Conclusions:1. The Gd-EOB-DTPA enhanced MRI can quantitatively evaluate liver function.2. There is a potential for Gd-EOB-DTPA enhanced MRI in predicting the differentiation level of hepatocarcinoma.