Clinical Observation Of Treatment Of Primary Osteoporosis With Methylene Diphosphonate (MDP) Labeled By Technetium[(99)~Tc]

Objective:To discuss clinical efficacy in the treatment of primary osteoporosis with methylene diphosphate(MDP) labled by technetium [99Tc].Methods:80cases of primary senile osteoporosis patients were randomly divided into treatment group and control group,40cases in each group.The control group taked Caltrate-D film600mg/day for150days.Based on the therapeutic maneuver of control group, treatment group were treated with methylene diphosphate(MDP) labled by technetium [99Tc](22mg, once daily, intravenous drip, for ten times, subsequently with an intermission for15days) repeated six cycles. The bone turnover markers (Dpd, NTX. BALP and BGP in blood) were detected and compared separately in different period of before treatment,1month,3months and6months after treatment.The femoral greater trochanter and L1-4vertebral bone mineral density values were detected and compared separately in different period of before treatment, lmonth,3months.6months and12months after treatment.The VAS pain scores were graded and compared separately in different period of before treatment and10days,1month,3months and6months after treatment.Compare differences of bone turnover markers,bone mineral density and VAS pain score between the two groups of patients before and after treatment.Results:Bone turnover markers (Dpd, NTX, BALP and BGP in blood) in treatment group are lower than control group after1month(p>0.05),3months and6months(p<0.05),and the change rate of these markers in treatment group are much higher than those in control group.The bone density of femoral greater trochanter and lumbar1,3and6months after treatment between the two groups showed no statistically significant differences(p>0.05),but showed statistically significant differences12months after treatment(p<0.05).The score of pain degree showed statistically significant difference10days,1month,3months and6months after treatment(p<0.05). No adverse reactions.Conclusion:Methylene diphosphate (MDP) labled by technetium [99Tc] can effectually and safely lower the rate of bone turnover,increase bone quality,effectively relieve osteoporosis pain, improve life quality of patients with primary osteoporosis.