Expression And Clinical Significance Of Upa And Cath-d In Endometrial Carcinoma

ObjectiveTo investigate the expression of urokinase-type plaminogen activator (uPA) and cathepsin D (Cath-D) in endometrial carcinoma and the correlation of the expression with clinical pathological feature of endometrial carcinomaMethodsTen cases of normal endometrium specimens of which17cases was endometrium hyperplasia tissues while31cases was endometrial cancer specimens, were analyzed using immunohistochemistry. The relationships among uPA and Cath-D in the endometrial cancer were analyzed by χ2test, Fish’s exactly test and Pearson test.Results1. The positive expression rates of uPA and Cath-D in the endometrial carcinoma tissue were significantly higher than those in the endometrial hyperplasia tissue and the normal endometrial one’s respectively(P＜0.05).2. There’s no significance between the endometrial hyperplasia and the normal one’s in the expression of uPA and Cath-D. uPA and Cath-D expression varies according to the disease stage, histological grade and myometrial invasion of endometrial carcinoma (P＜0.05).3. Cath-D positive cases were significantly positively correlated with uPA positive cases(r=0.673, P＜0.05).Conclusions1.The interaction between uPA and Cath-D plays a coordination role in the invasion and metastasis endometrial carcinoma.2.Cath-D can promote uPA in the process of invasion and metastasis, so uPA and Cath-D may be important indexes to predict the prognosis of endometrial carcinoma.