| Purpose:To observe the expression of BAIl in normal kidney tissue and kidney cell carcinoma (RCC) tissue, analyze the relationship between the clinical pathological parameters of RCC and their correlation, and investigate their roles in the occurrence, progress, invasion and metastasis in RCC, in order to provide help for the diagnosis and treatment of RCC.Methods:1.The expression of BAIl in27cases of normal kidney tissues,88cases of RCC tissues was detected by immunohistochemistry.2.The expression of BAIlmRNA in20cases of normal kidney tissues,20cases of RCC tissues was evaluated by reverse transcription-polymerase chain reaction (RT-PCR).Result:l.The expression of BAIl in various pathological types of RCC was significantly lower than that in normal kidney tissue(.P<0.05);2. The expression of BAIl in RCC was not correlate with the patients’age and sex (P>0.05), but associated with the tumor grade, Robson staging and lymph node metastasis (P<0.05);3. The expression of BAIl in Clear cell carcinoma was negatively correlated with Robson staging(P<0.05);4. The expression of BAIl mRNA in RCC was significantly lower than that in normal kidney tissue.(P<0.05);Conclusions:The protein and mRNA positive expression rate of BAIl in normal kindney tissue, was gradually reduced in RCC tissue, and was associated with the tumor grade, Robson staging and lymph node metastasis. The lower expression of BAIl can disorder the regulation of kidney cell, result in abnormal cell proliferation, promote the development of RCC, and was associated with the invasion and metastasis of RCC. Observing the expression of BAIl may provide some help in clinical diagnosis and treatment of RCC. |
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