Studies In Colon Cancer18F-FDG PET/CT SUV Values And Clinical Characteristics And Tumor Markers

Objective: Objective: To explore the clinical value of18F-FDGPET/CT in the diagnosis of colon cancer and correlative analysis ofrelationship between maximum standardized uptake value (SUVmax) andthe clinicalmanifestation, tumor markers.Subjects and Methods：(1)54patients who were observed to beinvolved in colon tumor in the First Hospital of Jilin University betweenOctober2011and February2014were detected by PET/CT imagingexamination, and41cases have a positive role in the histopathology orclinical follow-up of colon cancer Diagnostic accuracy of PET/CTimaging examination was evaluated, and sensitivity, specificity, positivepredictive value and negative predictive value were analyzed.(2)According to age, sex, lesion site, the vertical thickness of the lesion,lesion length along the intestine, lymph node metastasis, distantmetastasis, CA199, CEA, CA242level,41patients with colon cancerwere divided into different groups and SUVmax were calculated.(3) In41colon cancer cases, pearson correlation analysis was used to evaluatethe correlations between SUVmax values and patients age, intestinallesions length, vertical thickness of the lesion, CEA, CA199and CA242level Results:(1) Sensitivity, specificity, positive predictive value andnegative predictive value of18F-FDG PET/CT was93.1%、80.0%、95.3%and72.7%respectively。(2) SUVmax values of men and women groupwith colon cancer patients was considered statistically significant (P<0.05). In the vertical thickness≥10mm with lesions <10mm betweenthe groups in lymph node metastasis and distant metastasis than thosewithout lymph node metastasis and distant metastasis group, there werestatistical significance in SUVmax value(P<0.05). There was nosignificant difference of SUVmax values among the different lesion sitesof the group (P>0.05). SUVmax values in <60years and≥60yearsgroup, there was no statistical difference between the groups (P>0.05).There was no significant difference in SUVmax between CEA, CA199,CA242elevated group and the normal group (P>0.05).(3) SUVmaxvalues are strongly correlated with the vertical thickness of the lesion (P>0.05).Conclusion:18F-FDG PET/CT offered higher sensitivity, specificityand positive predictive value1in the diagnosis of colon cancer.2. Patientsex, lesion vertical thickness, lymph node metastasis and distantmetastasis of colon lesions factors may affect SUVmax values.3.SUVmax was positively correlated with the vertical thickness of the lesion.