40Patients Clinical And Pathological Characteristics Of Primary Sjogrensyndrome (Primary Sjogrensyndrome, PSS) Combined With Kidney Damage

Objective:To investigate the clinical and pathological characteristics ofprimary sjogrensyndrome (primary sjogrensyndrome, pSS) combinedwith kidney damage.Methods：Selected40patients who were diagnosed with pSS complicatedwith kidney damage in Second Hospital of Jilin University duringJanuary2009-July2013,and retrospective analyzed the clinical andpathological characteristics.Results：The average age of the patients was52.15years old(18-78), ofwhich39cases (97.5%) were female, only1case (2.5%) was male. Ofwhich22cases (55%) had the symptom of xerostomia,and20cases hadthe symptom of dry eyes. In all patients,35cases (87.5%) showed therenal tubular injury,25cases (62.5%) showed glomerular injury,5cases(12.5%) presented with nephrotic syndrome,and11cases (27.5%) had mild renal failure.38cases (95%) presented anti SS-A increased,21cases (52.5%) presented anti SS-B increased,20cases (50%) presentedanti SS-A and anti SS-B increased,and only1cases (2.5%) presentedanti SS-A, anti SS-B and negative.23cases (46%) appeared rheumatoidfactor increased,8cases (20%) appeared CRP increased,8cases (20%)appeared anticentromere antibodies posetive, and20cases (50%)appeared IgG increased.8patients underwent renal biopsy,4cases (50%)showed membranous nephropathy,1cases (12.5%) showed IgAnephropathy combined with renal arteriolar sclerosis,2cases (25%)showed chronic tubulointerstitial lesions,1cases (12.5%) showedglomerular minor lesion, and all of the8cases had segmental or diffusehyperplasia of glomerular mesangial cells.Conclusions：pSS was prone to have kidney damage, renal tubular damage wascommon, the kidney biopsy was helpful to clinical diagnosis and guidingtreatments.