Association Of Rs4938723、rs7372209with ESCC Risk And Sulfotransferase SULT1A1Arg213his Polymorphism With Cancer Risk

Esophageal cancer is one of the most aggressive cancers in the world. Its morbidityhas obvious differences between ethnic groups, especially more common in Asia.Esophageal cancer has two main types: esophageal squamous cell carcinoma (ESCC)and esophageal adenocarcinoma (EADC). ESCC is a common type of cancer in China,with a relatively high frequency and poor prognosis. Many factors may increase the riskof ESCC, including genetic factors and environmental risk factors. This study had twopurposes. One was conducted to evaluate the association between pri-miR-34b/crs4938723, pri-miR-26a-1rs7372209and ESCC susceptibility in a Chinese population.The other was to assess the association of SULT1A1Arg213His polymorphism withrisk of cancer.This study included1109ESCC cancers and1275healthy controls recruited fromsoutheastern China. Through literature review and searching miRBase, we selectedpri-miR-34b/c rs4938723and pri-miR-26a-1rs7372209as the target SNPs. rs4938723T>C locates in the CpG island in the promoter of pri-miR-34b/c. rs7372209locates inthe5’ UTR of pri-miR-26a-1from G to A. Genotyping was detected using a SNaPshotMultiplex System, and the association was determined with OR and95%CI adjustedfor age, sex, smoking and drinking.We found that:1. pri-miR-34b/c rs4938723(T>C) is associated with ESCCsusceptibility. The CC genotype was associated with a significant decreased risk ofESCC compared with the TT/TC genotypes (P=0.007, OR=0.82,95%CI=0.71-0.95).Stratified by age, sex, smoking and drinking, we found age, sex and smoking status canaffect the association this locus and ESCC risk.2. pri-miR-26a-1rs7372209(G>A)didn’t show association with ESCC in this population. And after stratified analyses, we also found nothing significant. Conclusion: The present study shows pri-miR-34b/crs4938723was associated with ESCC, and the association between pri-miR-26a-1rs7372209and ESCC susceptibility needs further study.Meanwhile, we found SULT1A1Arg213His is a hot SNP locus that is reported tobe associated with many kinds of cancer risk. However, the findings are conflicting. Forbetter understanding of this SNP site and cancer risk, we summarized available data andperformed this meta-analysis. Data was collected from the following electronicdatabases: PubMed, Web of knowledge and CNKI. The strength of association wasassessed by odds ratio (OR) and the corresponding95%confidence interval (95%CI).We found this polymorphism can increase cancer risks on the full data set in all models(heterozygous: OR=1.08,95%CI=0.99-1.18, P=0.07; homozygous: OR=1.20,95%CI=1.03-1.39, P=0.02; dominant: OR=1.11,95%CI=1.02-1.21, P=0.02; recessive:OR=1.16,95%CI=1.02-1.32, P=0.03and allelic model: OR=1.11,95%CI=1.03-1.19,P=0.005). The present meta-analysis suggests that SULT1A1Arg213His polymorphismmight contribute to increased cancer risk, especially for breast cancer and UADTcancer.