Intraoperative¹²⁵I Brachytherapy Combined With Endocrinotherapy For Prostate Carcinoma

Object i ve:Study and prel iminary evaluation of the perineum ultrasound guided125I radioactive particles implantation combined endocrine therapy to treat the clinical curative effect and complications of prostate cancerMethods:Retrospective appl i cat ion of1251radioactive particles implantation combined39patients with endocrine therapy for prostate cancer,, Observe and analyze the treatment effect,and complications.Results:This group of39patients were successfully completed particles implantation, operation time,40-150min, an average of65min, implanted particle number32-70, an average of52. Postoperative hospitalization time5to7days, an average of6.2days. Postoperative patients with surgery for regular follow-up, no39patients were lost to follow-up, the follow-up time12-67months, an average of36.2months. The full1year follow-up39cases, postoperative1PSA in0-90ng/ml,3.98ng/ml.33patients (84.6%), and completely effective part of effective4cases (10.2%), invalid in2cases (5.2%);35cases were followed up for3years,3years after the PSA to45in0.01ng/ml,1.8ng/ml,29cases (82.9%), and completely effective part of effective5cases (14.3%), invalid in1case (2.8%).17cases were followed up for5years, postoperative PSA in0.01-1.1n g/ml,0.23ng/ml, are perfectly valid.39cases with prostate volume and prostate specific antigen (PSA) reduced to some extent,3cases of metastases in patients with bone metastases are different degree of narrow, preoperative bone pain and urination were improved, and no severe complication such as urinary retention and bloody.4cases died during follow-up, including3cases of preoperative has found that prostate cancer and bone metastases (1case died two and a half years later,2cases died after4years), another1case died3years after other system diseases.Conclusion:125I radioactive particles implantation unite the endocrine therapy for clinical staging of prostate cancer patients have curative effect. To has lost the best operation time of middle-late prostate cancer patients provides a choice of clinical treatment. It has small trauma, easy to operate, short hospital stay, fewer complications, reliable curative effect, etc. Its effect in inhibiting tumor growth, relieve pain, both at home and abroad, the widespread recognition and identification. Therefore, under the condition of the conditions and equipment allow, radioactive particles implantation combined endocrine therapy is a method for the treatment of prostate cancer is safe and effective.