Different Syndrome Types Of Liver Cirrhosis Ascites Diuretic Effect Clinical Observational Study

Objective:To observe the effect of different syndrome types diuretic therapy, on the one hand, studying the relation between the curative effect of diuretics and TCM syndrome types, on the other hand, supporting the development of the type of syndrome and disease.Method:Collection of hepatitis b cirrhosis ascites and invalid patients treated by sodium limit rest, a total of182patients,90cases meet the inclusion criteria, according to the liver cirrhosis ascites syndrome types of TCM diagnostic criteria,25cases of qi stagnancy and wet resistance, damp and hot accumulate knot type23cases, spleen and kidney Yang deficiency type24cases,18cases of liver and kidney Yin deficiency type. Recording the weight of each patient,6, urine output, symptoms, signs, tongue and pulse condition, testing various syndrome in patients with liver cirrhosis ascites of liver function, renal function, electrolyte, observing the type’s relationship with electrolytes and renal function.According to the diuretic therapy treatment, weekly review the indicators, adjust the diuretic dose, total course of4weeks, to observe the effect of each card type diuretic therapy.Results:1) Electrolyte in every syndrome of TCM type changing trend for qi and blood, wet resistance type> damp and hot accumulate knot type>spleen kidney Yang deficiency type> liver-kidney Yin deficiency type was statistically significant, and wet resistance type is higher than other three type (P<0.05). Potassium, and moisture resistance type is higher than the other three type without statistical significance. Renal function, creatinine comparison each syndrome type of traditional Chinese medicine creatinine trends for liver and kidney Yin deficiency type> spleen kidney Yang deficiency type>damp and hot accumulate knot>heat and wet resistance, with statistical significance. Liver and kidney Yin deficiency type is higher than other three type (P<0.05). Every syndrome of TCM type urea nitrogen changing trend for the heat and wet resistance type<damp and hot accumulate knot type<spleen kidney Yang deficiency type<liver-kidney Yin deficiency type was statistically significant, which is lower than the spleen and kidney Yang deficiency qi stagnancy and wet resistance, liver and kidney Yin deficiency (P<0.05), damp and hot accumulate knot type below the liver and kidney Yin deficiency type (P<0.05).2) Diuretics are losing weight, four groups of patients after treatment compared with before treatment itself, with statistical significance. The weight loss of qi stagnancy and wet resistance after treatment significantly higher than the other three type (P<0.05).3) Diuretic treatment and wet resistance type healed in5cases,16cases were markedly improved,3cases ineffective in1case, and the effective rate was96%. Damp and hot accumulate knot recovered in1case,7cases had marked effect,12cases effective,3had no effect, the effective rate was87%. Spleen and kidney Yang deficiency type recovered in1case,9cases had marked effect,10cases were effective,4had no effect, the effective rate was83%. Liver and kidney Yin deficiency type0cases cured,1case had marked effect, effectively in5cases,10cases were invalid, the effective rate was38%. Diuretic effect from diminishing and wet resistance type to the liver and kidney Yin deficiency type was statistically significant, liver and kidney Yin deficiency type efficient significantly lower than the other three type (P<0.05).Conclusion:the liver cirrhosis ascites disease development trend for the heat and wet resistance type to the spleen and kidney Yang deficiency type, liver and kidney Yin deficiency type development. Liver cirrhosis ascites diuretic effect by wet type resistance to the liver and kidney Yin deficiency and qi stagnation type.