Relationship Of SOCS3, ER And Intrauterine Adhesions

Objective: To study the relationship of SOCS3,ER and intrauterine adhesions.Methods: Detect the protein expression of SOCS3and ER in intrauterine adhesionstissue of human in50cases of recurrent spontaneous abortion by immunohistochemistry.50cases of RSA were classificated to I-V according of ESGF. Analyze the relationshipbetween SOCS3、ER and intrauterine adhesions.Results:1. Expression of SOCS3was detected in cytoplasm， In intrauterine adhesionstissue,there is a trend between the degree of intrauterine adhesions and the expression ofSOCS3(P=0.0003<0.01); the more severe intrauterine adhesions, the higher the expressionof SOCS3.2. Expression of ER was detected in cytoplasm,nucleus;In intrauterine adhesionstissue,there is a trend between the degree of intrauterine adhesions and the expression ofER(P=0.0007<0.01); the more severe intrauterine adhesions, the higher the expression ofER..3. SOCS3and ER expressions in intrauterine adhesions tissue were correlated withthe degree of intrauterine adhesions(Kappa=0.483，P=0.001).Conclusions:1. SOCS3, ER may play an important role in the pathogenesis of intrauterineadhesions, but whether it is by SOCS3regulation of JAK-STAT pathway to causeintrauterine adhesions occur, needing further study.2. SOCS3, ER may participate in the formation of intrauterine adhesions through theinteraction of each other.