The Effects Of Different Amount Of Induction Meterage Midazolam On The Aged Lung Cancer Operation Patients’ Anesthesia Effect And Anesthesia Recovery

Objective:To compare The Effects of Different amount of Induction MeterageMidazolam on the aged Lung Cancer Operation Patients’ AnesthesiaEffect and Anesthesia RecoveryMaterials and methods:Choosing47patients who are waiting the right date to have Lungcancer operation, ASA:II or III,age:60-77,random form two groups:experiment(A),comparison(B),30patients in each group. Excluding thepatients in the deep abnoral function, cardiovascular diseases and abnoralfunction of the liver and kidney.Don’t give patients medicine before anesthesia. When come into theoperation room, monitor the electrocardiogram, invasive blood pressure,heart rate, SpO2pulse O2saturation, to contact BIS.During the Anesthesia Induction, give Midazolam0.1mg/kg byintravenous injection to the patients in group A;0.05mg/kg in group B.The methods of giving medicine are the same in two groups, that isAtracurium0.15mg/kg, Fentanyl citrate4ug/kg, Etomidate fat emulsion0.3mg/kg.After5mins the bronchial catheter was done well, we shoulduse bronchofiberscope A-GPS, then contact the machine of anesthesia.Keeping the airway pressure<30cmH2O,35mmHg<PETCO2<45mmHg.Continuous anesthesia: During the operation, we should targetcontrol input Propofol and Remifentanil, incontinuity intravenousinjection atracurium, and adjust the amount of input of Propofol andRemifentanil, keep40〈BIS〈60. Stop the using of muscle relaxant, before30mins the end of the operation, stop the using of the muscle relaxantafter the patients can breathe by themselves.Stop using of the Anesthesia medicine when the operation is over, atthe same time give flumazenil0.5mg to control the left of Midazolam.We should write down clearly the result of the average arterial bloodpressure, heart rate, degree of blood oxygen saturation,at3mins laterinduction anesthesia(T1), input tracheal catheter(T2), the beginning ofoperation(T3),an hour after the beginning of the operation(T4), the end ofthe operation(T5),take out of the tracheal catheter when the patients wakeup(T6). And keep the time between stopping the medicine and openingthe eyes, the time between taking out the tracheal catheter and waking up,the time staying in PACU, Prince-Henry and the agitation conditions, andthe amount of Propofol and Remifentanil.The result will be statistical dealed by SPSS17.0.Results:(1) the two groups in age, height, weight, sex ratio, operation time and blood loss difference non statistics significance.(2) in patients with circulatory and respiratory fluctuations:experimental group compared with the control group, no significantdifference.(3) patients after open time, extubation time and residence time ofanesthesia recovery room, the experimental group was significantlyshorter than that in the control group (P <0.05).(4) the value of BIS and there was no significant difference betweentwo groups of patients recovery time.(5) the accumulative total amount of propofol and remifentanil usedin the experimental group was significantly less than that of the controlgroup (P <0.05).(6) of two groups were2male patients with urethral discomfort orpain in the postoperative agitation, after remission, no statisticaldifference.Conclusion:For the clinical operation in elderly patients with lung cancer duringinduction of anesthesia with right amount increase midazolam dose,postoperative and the amount of fluorine Masini antagonism; caneffectively improve the recovery quality, better controllability, reduce themaintenance of anesthesia drug dosage, and does not affect the smoothdegree of anesthesia, is a safe, feasible dosing regimen, the elderlypatients in peri operation period of more safe and comfortable.