Research On The Prevalence And Clinical Significance Of Antoantibodies In Patients With Drug-induced Liver Injury

Drug-induced liver injury (DILI) refers to the drugs during treatment due todrug or its metabolites cause hepatotoxicity damage or liver of drugs andmetabolites of the allergic reactions caused by disease. DILI is divided into twokinds, one kind is related to drug toxicity itself and is predictable, dosedependent and can be copied, Another is related to the idiosyncrasy of patientssuch as genetic, metabolism and other factors, which is also called idiosyncrasydrug-induced liver injury. The occurrence of the latter has nothing to do withdrug dose, often occurs when using the safe drug dose. Idiosyncrasydrug-induced liver injury is always mediated by immunity, accompanied by therise of immunoglobulin and positive autoantibodies, such as ANA, SMA, etc, soit is often misdiagnosed as autoimmune hepatitis or other autoimmune liverdisease. As drug screening is more and more strict, and the awareness of peopleis greatly increased, people will try to avoid using drugs of hepatotoxicity orcooperate using liver-protection drugs when using these drugs. However,Idiosyncrasy drug-induced liver injury which is associated with people’s owngenetic and metabolism is unpredictable. It will account for the dominant.Object: To investigate the autoantibody detection rate of DILI and itsclinical significance, the relationship between autoantibody detection rate andgender, age, liver damage model, prognosis and drug category.At the same time,the types and titer of autoantibodis are also researched. Materials and methods: A retrospective analysis was performed on theclinical data of patients received and cured by the department ofhepatic-billiary-pancreatic medicine of the first hospital of Jilin University,include132patients with drug-induced liver injury between January2009toDecember2013and154patients with virus hepatitis (include96patients withchronic hepatitis B and58patients with chronic hepatitis C) between January2012to December2013. The studied factors included age, sex, names andcategories of toxic drugs. time of onset, autoantibodies, liver function, bloodcoagulation function, etc.Results and conclusion: Autoantibody detection rate of DILI is60.61percent and is higher than that of hepatitis B (39.39percent). It has nothing to dowith gender, age, liver damage model and grade of the CHILD exceptmedication time. The longer the medication time, the higher the detection rate.The autoantibodies of DILI is given prior to middle and low drop degree, themain categories is ANA, SMA, AMA, and the detection rate of them is56.06%，12.88%,3.03%respectively. Traditional Chinese medicine and westernmedicine have similar possibility of inducing autoantibodies, with no statisticaldifference.