Shotr-term Therapy Efficacy Of Folate, Vitamin B₆, Vitamin B₁₂ On Patients Of Acute Ischemic Stroke With Hyperhomocysteinemia

Objective:To study the short-term therapy efficacy of folate,VitaminB6,Vitamin B12on patients of acute ischemic stroke with hyperhomocysteinemia.Methods:One hundred and eighteen acute ischemic stroke patients withhyperhomocysteinemia were randomly divided into two groups, interventiongroup and non intervention group. Both groups were given conventionalvasodilator,anti-platelet aggregation and neurotrophic therapy,and measure theNIHSS score to evaluat the degree of neurological impairment.The experimentalgroup were further interventionally given folic acid tablets on the basis of5mgt.i.d+vitamin B610mg t.i.d+Mecobalamin tablets0.5mg t.i.d for10days.The plasma levels of Hcy, folate and Vitamin B12were examined in thefirst day of admission and10days after treatment.And measure the NIHSSscore in5days and10days after treatment.Results:, There was no significant difference (P>0.05) in the levels ofserum hcy,folate,Vitamin B12, and also gender, age and common risk factorsof cerebrovascular disease patients comparing the intervention group and nonintervention group before intervention, the two groups were comparable.Patients enrolled in the low folate hyperlipidemia up to92%, low vitamin B12viremiaup to38%.Men accounted for88.98%, accounting for11.01%of women.Thehomocvsteine levels were significantly reduced after10days treatment,whereaslevels of folate and Vitamin B12were significantly increased,the difference wasstatistically significant (P <0.05) compared with pre-treatment in theintervention group.There were no significant change (P>0.05) in the levels ofhcy, folic acid and Vitamin B12in the non intervention group.The serum levelof Hcy in intervention group was significantly lower than that of nonintervention group after intervention,the levels of folic acid, Vitamin B12ofintervention group were significantly higher than that of non interventiongroup,the difference was statistically significant (P <0.05) compared withpre-treatment.The number of sicker patients were both4in the interventiongroup and non intervention group,the two groups were noncomparable（P>0.05）.The NIHSS scores of both groups in the first day of admission and5days,10days after treatmentat was no statistically significant (P>0.05).Conclusions:Hyperh-omocysteinemia has obvious gender differences,Male ishigher than female significantly.The levels of serum folate, Vitamin B12arenegatively correlated to the levelof serum Hcy.Folic acid, Vitamin B6andmethylcobalamin can effectively reduce the level of serum hcy in acuteischemic stroke patients with hyperh-omocysteinemia in the short term.whenthe levelof serum Hcy in acute ischemic stroke patients with hyperhomocysteinemiawas reduce rapidly in the acute phase,Can not reduce the progress of patients.Symptoms of neurological impairment cannot be improved after Hhcywas controlled In the acute phase.