The Signiifcance Of Nerve Conduction Studies And Current Perception Threshold In The Diagnoisis Of Diabetic Peripheral Neuropathy

Objectives：To investigate the significance of nerve conduction studies andcurrent perception threshold in the diagnosis of diabetic peripheral neuropathy，especially current perception threshold to diabetic small fiber neuropathy．Methods：80patients with type2diabetic mellitus were selected according to1999WHO diabetic mellitus diagnosis criteria．Nerve conduction studies(NCS) andcurrent perception threshold (CPT) were measured in80patients and their resultswere compared．The data was compared between the two groups by X2test，P<0.05was considered statistically significant．Results：1.The abnormal rate of LAT,AMP,CV of MNCS were respectively5.3%,7.8%,9.4%，of SNCS were respectively10.3%,31.6%,19.7%. The difference betweenthem was statistically significant (P<0.05).2.The abnormal rates of A-beta fibers, A-delta fibers, C-fibers were respectively34.1%,41.9%,42.8%. The difference between them was statistically significant(P<0.05), but A-delta fibers and C-fibers is not.3.The abnormal rates of NCS, A-beta fibers, A-delta fibers, C-fibers in lowerlimb were respectively29.3%,41.9%,51.3%,49.4%; the abnormal rates ofNCS,A-beta fibers, A-delta fibers, C-fibers in upper limb were respectively22.2%,26.3%,32.5%,36.3%;the abnormal rates of them in lower limb are higher thanthose in the upper limbs, the difference are statistically significant (P<0.05).4.The abnormal rates of NCS,A-beta fibers, A-delta fibers, C-fibers in the groupwith clinical symptom were respectively33.4%，46.2%，53.3%，52.7%; withnon-symptom were15.8%,17.6%,26.5%,29.4%respectively; the abnormal rates ofNCS,A-beta fibers, A-delta fibers, C-fibers in the group with a course of disease>5years were respectively29.3%,40%,46.8%,50%; with a course of disease≤5years were respectively21.2%,28.0%,34.8%,32.6%;The difference between them wasstatistically significant (P<0.05).5. The abnormal rate of NCS and CPT were respectively58.8%,77.5%,Thedifference between them was statistically significant. The sensitive parameter of CPTin the screening of diabetic peripheral neuropathy was87.2%.Conclusion：1. The nerve conduction studies (NCS) were used as a standard criteria, NCSand CPT showed linear correlation in evaluate of diabetic peripheral nerve.2. CPT could detect the impairment of diabetic peripheral nerve and reveal theimpairment earlier than NCS, and CPT is useful for screening DPN.