A Study Of The Relationship Between Subclinical Hypothyroidism And Three Blood Cells

Objective Thyroid hormone has important effect on the blood system. Abnormal thyroid function can increase the risk of abnormal peripheral blood cells. Hyperthyroidism (PHT) and hypothyroidism can lead to abnormal cell in peripheral blood of three lines, especially in patients with hypothyroidism, anemia rate higher. Subclinical thyroid disease only serum TSH level change, whether it will cause the three systems in peripheral blood cell changes, less reported. The objective of this study was to observe the changes in peripheral blood of three cells in patients with subclinical hypothyroidism, to investigate the relationship between them and its clinical significance, so as to provide evidence for early screening and intervention of subclinical hypothyroidism.Methods From January2011to June2013,193cases with subclinical hypothyroidism were found as research object(referred to the subclinical hypothyroidism group) in The Affiliated Hospital of Shaoxing University of Zhejiang province. In the corresponding period,772cases of normal thyroid function were examined as the control group(referred to the euthyroid group). Compare the differences between the two groups of thyroid function, blood routine, liver and kidney function and blood lipids and other indictors, as well as the prevalence of anemia, and to analyze the risk factors of anemia.Results Compared with euthyroid group, subclinical hypothyroidism group of hemoglobin and red blood cells decreased significantly (P<0.05), white blood cell (WBC), lymphocytes (L), mononuclear cells (M) were increased (P<0.05); immunoglobulin (G) was higher than that of euthyroid group, difference significant (P <0.05); there was no significant difference in other indexes (P>0.05). The prevalence of anemia increased in subclinical hypothyroidism group Compared with euthyroid group (6.2%VS.2.7%, P<0.05). Pearson correlation analysis showed that, in the population of subclinical hypothyroidism and normal thyroid function, FT3, FT4and hemoglobin (Hb), red blood cell (RBC) were positive correlated (r=0.364, P=0.000, r=0.328, P=0.000; r=0.288, P=0.000, r=0.243, P=0.000). Logistic regression analysis showed that subclinical hypothyroidism (OR=2.440,95%CI,1.100-5.411, P=0.028) and low FT4(OR=0.793,95%CI0.633-0.993, P=0.043) were the independent risk factors of anemia.Conclusion Subclinical hypothyroidism can cause peripheral blood cells change, especially hemoglobin decrease. The prevalence of anemia was significantly higher in Subclinical hypothyroidism. Subclinical hypothyroidism and low FT4are independent risk factors for anemia.