Effect Of Compound Heart Of The High-fat Diet Rabbits Bi Tang Endothelial Function And Inflammatory Factors

Purpose:To observe the effect of compound Heart paralysis of "High-fat diet for+Inhibit the metabolism+Immune injury+Femoral artery injury"hyperlipidemic rabbits and cell inflammatory factor, vascular endothelial function, and to explore its mechanism of action,Provide an experimental basis for clinical treatment of compound Heart paralysis.Method:50New Zealand rabbits were randomly assigned,10divided into normal group, model group40.Modules made using "High-fat diet for＋Inhibit the metabolism＋Immune injury＋Femoral artery injury" method,Respectively, in seven weeks after modeling, modeling of New Zealand rabbits demonstrated significantly elevated blood lipids and lipid femoral artery has plaque formation, and then randomly divided into four groups.That aspirin group, simvastatin group, compound Heart paralysis group, high-fat diet group. In addition to the normal and high-fat diet group were administered, and to continue to provide high-fat diet, normal to the normal diet until the end of the trial.Outcome measures included blood lipids:triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and associated with inflammatory cells in atherosclerotic factor C-reactive protein (CRP), interleukin-6(IL-6), tumor necrosis factor-a (TNF-a) and vascular endothelial cell function reflects endothelin-1(ET-1), nitric oxide (NO) content.Result:compound Heart paralysis on animal models have good blood lipid regulation, After administration of serum TC, TG and LDL-C levels decreased, and make the blood CRP, IL-6, reduce the level of ET, increased NO levels.Conclusion:Compound heart Bi Tang anti-atherosclerotic mechanisms of action may be related to regulating blood lipids, anti-inflammation of the lining of blood vessels, improve vascular endothelial function.