Curcumin In Heart Failure Rat Function And Mechanism Research

objective to establish heart failure rats model, based on this model are respectivelystudied curcumin in heart failure rat blood flow dynamics and myocardial tissuepathology change effect, at the same time analysis Brain natriuretic peptide in curcumintreatment of heart failure mechanism.Methods set JiaShouShu group, the control group, low dose group (50mg/kgcurcumin), medium dose group (75mg/kg) and high dose group (100mg/kg), in order torats signs change, rat body weight, heart heavy, heart heavy/weight, heart rate and gaschange and rats blood dynamics change to evaluate heart failure rats model is stable andreliable； In the treatment of12weeks after the left ventricular systolic blood pressure(LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular pressure changeis the biggest rate (+dp/dtmax and-dp/dtmax) and myocardial tissue HE dyeing asevaluation curcumin in heart failure rat influence index； Acquisition rat myocardialthick cell tissue, using Western blot test Caveolin-3expression and ELISA detectionBNP expression to reveal different dosages curcumin treatment of heart failure processCaveolin-3and BNP expression rule.Results heart failure model rats compared with controls, there is obvious difficultybreathing aggravate, death, hair colour and lustre is abnormal and abnormal activities；And weight loss, heart heavy and heart heavy/weight ratio decreased, fast heart rate andoxygen saturation decline； Left ventricular systolic blood pressure (LVSP), leftventricular end-diastolic pressure (LVEDP), left ventricular pressure change is the biggestrate (+dp/dtmax and-dp/dtmax), aortic systolic blood pressure (ASP), aortic diastolicpressure (ADP) and between the aorta and left ventricular pressure difference (TAG), can be used as direct response heart failure model is built； Curcumin treated rats leftventricular systolic blood pressure (LVSP), left ventricular diastolic pressure (LVEDP)and left ventricular maximum contraction/diastolic velocity (plus or minus dp/dtmax)were JiaShouShu group recovered to the same level of myocardial tissue pathologicaldyeing are returned to normal, did not see the myocardial cell swelling, gap decreases andthe myocardial fibers limitations fracture, myocardial mass in the phenomenon such asblood vessels； As the dosage of the curcumin increases, Caveolin-3expressiongradually increase, with the dosage of curcumin increases, BNP expression graduallyreduced.Conclusion curcumin has cure or alleviate heart failure rat illness effect, and withthe increase of the dose of curcumin in the treatment of curcumin, the better the results；Curcumin may through some mechanism or by changing the Caveolin-3and BNPexpression and play heart failure treatment effect.