The Characteristic Of Glucose Fluctuation And Glycemic Parameters For Continuous Glucose Monitoring In The Older Whose Ages Exceed80Years Old

Objective:To research the characteristic of glucose fluctuation and reference values of glycemic parameters for the older whose ages exceed80years old.Methods:Twenty-four individuals whose ages exceeded80years old with normal glucose regulation were observed with continuous glucose monitoring system(CGMS)fOr3days. Indexes in CGMS were analyzed, such as:mean level of24h blood glucose values(24h MBG)and standard deviation(SDBG),mean amplitude of glycemic excursions (MAGE) and absolute means of daily differences(MODD), the largest amplitude of glycemic excursions(LAGE), percentage of time above7.8mmol/L or below3.9mmol/LoResults:(1) the blood glucose of the NGR whose ages exceeded80years old fluctuated all the day. The period of low blood glucose occurred at night and before sleep in a day. The blood glucose level exceeded11.1mmol/L at some time in the day, and the peak blood glucose level relatively concentrated at1-2hours after a meal, with after-breakfast hyperglycemia most prominent.(2) The reference ranges of the glycemic parameters were as follows:24h MBG(6.21±1.42) mmol/L SDBG (1.21±0.34) mmol/L, MAGE (3.13±1.26)mmol/L, MODD (1.03±0.28), Peak of intraday glucose value (9.5±1.70) mmol/L, Low intraday glucose value (4.22±0.50) mmol/L, LAGE (5.29±1.74) mmol/L. The percentage of time of the glucose level below3.9mmol/l is1.7%, The percentage of time of the glucose level between3.9and7.8mmol/l is85.2%, The percentage of time of the glucose level above7.8mmol/l is13.1%. Glucose level varied between3.8～10.7mmol/L in98%of the time。(3) The correlations between MODD and SDBG was positive (r=0.43, P<0.05)。MAGE was positively correlated with LAGE (r=0.813, P<0.05)。HbA1C was not related with MODD、MAGE、 SDBG(P>0.05),but related with OGTT2h blood glucose (r=0.47, P<0.05)Conclusion:The elderly are featured with their own blood glucose fluctuation characteristics and reference values of glycemic parameters which differ from other groups。CGMS have advantage to detect hyperglycemia and asymptomatic hypoglycemia, and it can be use as a more comprehensive observation of blood glucose fluctuation.