Expression And Significance Of Nodal Protein In Lung Adenocarcinoma

Object:To study the expression and clinical significance of Nodal which is regulated gene of epithelial mesenchymal transition (epithelial mesenchymal transition,EMT) in lung adenocarcinoma.Methods:The expression of Nodal protein in80cases of lung adenocarcinoma tissue normal lung tissue were checked by immunohistochemistry.The relations with the expression of Nodal protein and the multiple factors of age,gender,P-TNM stage,differentiation and lymph node metastasis were analyzed statistically.Results:The expression rates of Nodal protein in lung adenocarcinoma and normal lung tissue were72.5%and15%, respectively (P<0.05);Positive expression rate of Nodal in lung adenocarcinoma is significantly higher than that of normal lung tissue;The expression of Nodal was associated with P-TNM stage, differentiation and lymph node metastasis (P<0.05)(x2=6.920、8.283、4.979);The expression of Nodal protein was not associated with the age and gender.(F>0.05)(χ2=0.600,0.928).Conclusion:Nodal protein in cancer tissues of lung adenocarcinoma have higher expression rate in normal lung tissues, suggesting that Nodal protein with lung adenocarcinoma is closely related; The expression of Nodal is closely associated with P-TNM stage and differentiation, it may bring help to determine the prognosis of patients.