The Study Of The Correlation Between ABCC11Gene Single Nucleotide Polymorphism (SNP) And The Incidence Of Axillary Bromidrosis In Chinese Han Population

Objective:To study the correlation between ABCC11gene single nucleotide polymorphism (SNP) and the incidence of axillary bromidrosis in Chinese Han population.Methods:165patients with axillary odor attending outpatient were investigated and the relevance of cerumen and axillary odor was analysis; Immunohistochemisty were used to examine the expression of ABCC11in armpit full-thickness skin of patients and normal subjects; The single nucleotide polymorphism (SNP) of ABCC11was detected and analyzed.Results:164of165patients (99.4%) investigated have wet cerumen;The immunohistochemical result shows that ABCC11protein expressed more in apocrine gland cells of axillary bromidrosis patients; The SNP tests show that23of the25patients were GA genotype and the other2serious paitients were GG genotype,while AA genotype were correlated to the2normal subjects.Conclusion:axillary odor was an autosomal monogenic dominant trait, correlated with wet earwax. The SNP in ABCC11was the genetic cause of axillary bromidrosis:GG or GA lead to axillary odor while the AA allele presents the absent of odor; The ABCC11rs17822931Polymorphism Gâ†'A result in the reduction of ABCC11protein expression; The ABCC11gene has an important role in regulation of the function of the apocrine.