To Observe The Clinical Efficacy Of The Treatment Of Thrombolysis In Acute Cerebral Infarction

Objective:To compare the clinical therapeutic efficacy between simple arterial urokinase thrombolysis and mechanical thrombectomy combined with arterial urokinase thrombolysis in treating acute cerebral infarction and explore therapeutic differences.Methods:Emergency interventional therapy were carried in57cases with acute cerebral infarction cases indicated for arterial thrombolysis. Arterial thrombolysis using using urokinase combined with mechanical thrombolysis was employed in29cases (combination group) while pure arterial infusion of urokinase using urokinase was adopted in28cases (urokinase group). For combination group, intervention therapy includesd mechanical thrombectomy, balloon angioplasty, stent-thrombectomy and ensuing urokinase thrombolysis. For urokinase group, intervention therapy includes urokinase alone. CT scan was performed in all patients before/24-hour&1week after intervention. Postoperative treatment includes anti-platelet, anti-coagulation, dehydration, anti-free radical, neural resuscitation, blood pressure control, blood glucose control and other symptomatic supportive measures. All cases were evaluated by NIHSS before/24-hour,7-day&14day after intervention therapy.Results:Statistically significant difference of14-day NIHSS differential value before and after intervention therapy existed between combination and urokinase groups. Vascular recanalization rate of combination group was significantly higher while than that of urokinase group while recurrent bleeding rate of combination group after intervention therapy was significantly lower than that of urokinase group. Mortality of combination group was lower than that of urokinase group. Urokinase dosage of combination was significantly lower than that of urokinase group.Conclusions:1.The therapeutic efficacy of mechanical thrombectomy combined with arterial urokinase thrombolysis is superior to that of pure arterial infusion of urokinase. 2. Vascular recanalization rate of combination group is significantly higher than that of urokinase group.3.Recurrent bleeding rate of combination group after intervention therapy is significantly lower than that of urokinase group.4. Urokinase dosage of combination is significantly lower than that of urokinase group.6Figures,8Tables,49References.