Middle-aged Male Patients With Cirrhosis Retrospective Study Of Prognostic Factors

Objective: Looking affect the risk factors associated with the prognosis ofpatients with cirrhosis of the40to60age group, male, improve prognostic accuracy, inorder to reduce this population mortality over the same periodMethod: Collect40cases patients at the General Hospital of Shenyang MilitaryRegion from February2003to February2013, death from cirrhosis of the age between40～60years old, middle-aged men as death group.52cases are randomly selectedfrom the same age group and the same period cirrhosis survival patient in hospital as asurvival group. I collect38indicators, as follows:smoking, drinking, etiology, serumelectrolytes, liver and kidney function, blood coagulation indicators and complicationsof cirrhosis. First distribution of the cause of92patients are made frequency statistics,and multiple constituent ratio of two groups X~2test was used to analysis the causedifferences of death group and survival group,Second two of groups of complicationsare made frequency statistics,At last in addition to etiology37indicators that may affectits prognosis are conducted with univariate analysis, the statistically significantindicators (0.05,P <0.05) are placed into binary Logistic regression analysis,getting the main risk factors of impact prognosis of the40～60age group men cirrhosispatients.Results:1.The etiology of92patients: hepatitis B in57casess,62.0%of the totalnumber of cases;20patients with alcoholic liver disease, accounting for21.7%;10cases of cirrhosis due to other causes,10.9%of the total number of cases;5patientswith hepatitis C cirrhosis, accounting for5.4%of total number.2.The cause of deathgroup: hepatitis B26cases, alcoholic liver disease7cases, other causes3cases,hepatitis C4cases; cause of survival group corresponds to31cases,13cases,7cases,1case, use multiple constituent ratio of two groups X~2test, P_a=0.05=0.25>0.05,statistically no difference, temporarily can not believe that the cause of death group and survival group have differences.3.The death group complication frequency statistics:22cases of upper gastrointestinal bleeding,1case of spontaneous bacterial peritonitis,30cases of hepatic encephalopathy,17cases of hepatorenal syndrome,2cases ofhepatopulmonary syndrome,10cases of infection,5cases of portal vein thrombosis,14cases of primary liver cancer,40cases of ascites; survival group complicationscorresponding frequency statistics:13cases,1,11,0cases,0,3cases,2cases,5cases,23cases; the top three complications of death group: ascites, hepatic encephalopathy,upper gastrointestinal bleeding, survival group, the top three complications: ascites,upper gastrointestinal bleeding, hepatic encephalopathy.4. Death and survival groupsingle factor analysis: serum sodium, potassium, alkaline phosphatase, cystatin, totalbilirubin, direct bilirubin, albumin, prealbumin, creatinine, urea, PT, APTT, uppergastrointestinal bleeding, hepatic encephalopathy, hepatorenal syndrome, infection,primary liver cancer, ascites, and MELD(Model for end stage liver disease, end-stageliver disease model) score of19indicators statistically different5. Binary Logisticregression analysis of death and survival group: Statistically significant indicators areupper gastrointestinal bleeding, hepatic encephalopathy, serum potassium, directbilirubin, the regression coefficients respectively were6.00,5.42,2.79,0.03, they areindependent risk factors of the40～60age group men cirrhosis patients, and uppergastrointestinal bleeding and hepatic encephalopathy are major risk factors.Conclusion:1.The main cause of40～60age group of male patients with livercirrhosis is hepatitis B, followed by alcoholic liver disease, other causes, hepatitis C.2.Etiology are not risk factors for prognosis of40～60age group of male patientswith liver cirrhosis3.Male cirrhosis of the40～60age group are likely to suffer ascites,uppergastrointestinal bleeding, hepatic encephalopathy.4.Upper gastrointestinal bleeding, hepatic encephalopathy, serum potassium,direct bilirubin are independent risk factors that affect the prognosis of the40～60agegroup men patients with cirrhosis, and upper gastrointestinal bleeding and hepaticencephalopathy are major risk factors.